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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs.
Abuo-Rahma, Gamal El-Din A; Mohamed, Mamdouh F A; Ibrahim, Tarek S; Shoman, Mai E; Samir, Ebtihal; Abd El-Baky, Rehab M.
  • Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University 61519 Minia Egypt gamal.aborahama@mu.edu.eg +20 1003069431.
  • Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University 82524 Sohag Egypt.
  • Ibrahim TS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University Jeddah 21589 Saudi Arabia.
  • Shoman ME; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University Zagazig 44519 Egypt.
  • Samir E; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University 61519 Minia Egypt gamal.aborahama@mu.edu.eg +20 1003069431.
  • Abd El-Baky RM; Physical Chemistry, Department of Analytical Chemistry, Faculty of Pharmacy, Deraya University Minia 11566 Egypt.
RSC Adv ; 10(45): 26895-26916, 2020 Jul 15.
Article in English | MEDLINE | ID: covidwho-752449
ABSTRACT
The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people are already infected, about 500 000 deaths all over the world to date. Great efforts have been made to find solutions for this viral infection, either vaccines, monoclonal antibodies, or small molecule drugs; this can stop the spread of infection to avoid the expected human, economic and social catastrophe associated with this infection. In the literature and during clinical trials in hospitals, several FDA approved drugs for different diseases have the potential to treat or reduce the severity of COVID-19. Repurposing of these drugs as potential agents to treat COVID-19 reduces the time and cost to find effective COVID-19 agents. This review article summarizes the present situation of transmission, pathogenesis and statistics of COVID-19 in the world. Moreover, it includes chemistry, mechanism of action at the molecular level of the possible drug molecules which are liable for redirection as potential COVID-19 therapeutic agents. This includes polymerase inhibitors, protease inhibitors, malaria drugs, lipid lowering statins, rheumatoid arthritis drugs and some miscellaneous agents. We offer research data and knowledge about the chemistry and biology of potential COVID-19 drugs for the research community in this field.

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: RSC Adv Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: RSC Adv Year: 2020 Document Type: Article