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Ratios of neutrophil-to-lymphocyte and platelet-to-lymphocyte predict all-cause mortality in inpatients with coronavirus disease 2019 (COVID-19): a retrospective cohort study in a single medical centre.
Wang, Xue; Li, Xincheng; Shang, Yu; Wang, Junwei; Zhang, Xiaona; Su, Dongju; Zhao, Shuai; Wang, Qin; Liu, Lei; Li, Yupeng; Chen, Hong.
  • Wang X; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Li X; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Shang Y; Department of Respiration, Harbin City First Hospital, Harbin, 150081, China.
  • Wang J; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Zhang X; Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Su D; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Zhao S; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Wang Q; Department of Nephrology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Liu L; Department of Cadre's Ward, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Li Y; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Chen H; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Epidemiol Infect ; 148: e211, 2020 09 09.
Article in English | MEDLINE | ID: covidwho-752593
ABSTRACT
The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern. The current study aims to explore whether the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with the development of death in patients with COVID-19. A total of 131 patients diagnosed with COVID-19 from 13 February 2020 to 14 March 2020 in a hospital in Wuhan designated for treating COVID-19 were enrolled in the current study. These 131 patients had a median age of 64 years old (interquartile range 56-71 years old). Furthermore, among these patients, 111 (91.8%) patients were discharged and 12 (9.2%) patients died in the hospital. The pooled analysis revealed that the NLR at admission was significantly elevated for non-survivors, when compared to survivors (P < 0.001). The NLR of 3.338 was associated with all-cause mortality, with a sensitivity of 100.0% and a specificity of 84.0% (area under the curve (AUC) 0.963, 95% confidence interval (CI) 0.911-1.000; P < 0.001). In view of the small number of deaths (n = 12) in the current study, NLR of 2.306 might have potential value for helping clinicians to identify patients with severe COVID-19, with a sensitivity of 100.0% and a specificity of 56.7% (AUC 0.729, 95% CI 0.563-0.892; P = 0.063). The NLR was significantly associated with the development of death in patients with COVID-19. Hence, NLR is a useful biomarker to predict the all-cause mortality of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Platelets / Lymphocytes / Coronavirus Infections / Betacoronavirus / Neutrophils Type of study: Cohort study / Observational study / Prognostic study / Reviews Limits: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Infant / Middle aged / Infant, Newborn / Young adult Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article Affiliation country: S0950268820002071

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Platelets / Lymphocytes / Coronavirus Infections / Betacoronavirus / Neutrophils Type of study: Cohort study / Observational study / Prognostic study / Reviews Limits: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Infant / Middle aged / Infant, Newborn / Young adult Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article Affiliation country: S0950268820002071