Advances in understanding the initiation of HIV-1 reverse transcription.
Curr Opin Struct Biol
; 65: 175-183, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-752884
ABSTRACT
Many viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Human Immunodeficiency Virus (HIV), use RNA as their genetic material. How viruses harness RNA structure and RNA-protein interactions to control their replication remains obscure. Recent advances in the characterization of HIV-1 reverse transcriptase, the enzyme that converts its single-stranded RNA genome into a double-stranded DNA copy, reveal how the reverse transcription complex evolves during initiation. Here we highlight these advances in HIV-1 structural biology and discuss how they are furthering our understanding of HIV and related ribonucleoprotein complexes implicated in viral disease.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
HIV-1
/
Reverse Transcription
Language:
English
Journal:
Curr Opin Struct Biol
Journal subject:
Molecular Biology
Year:
2020
Document Type:
Article
Affiliation country:
J.sbi.2020.07.005
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