Antibody-dependent enhancement of coronavirus.

Wen, Jieqi; Cheng, Yifan; Ling, Rongsong; Dai, Yarong; Huang, Boxuan; Huang, Wenjie; Zhang, Siyan; Jiang, Yizhou

Wen, Jieqi; Cheng, Yifan; Ling, Rongsong; Dai, Yarong; Huang, Boxuan; Huang, Wenjie; Zhang, Siyan; Jiang, Yizhou.

Wen J; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 1900391007@email.szu.edu.cn.
Cheng Y; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: chengdiefan2017@email.szu.edu.cn.
Ling R; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017182010@email.szu.edu.cn.
Dai Y; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: daiyarong2019@email.szu.edu.cn.
Huang B; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: huangboxuan2017@email.szu.edu.cn.
Huang W; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: 2017222014@email.szu.edu.cn.
Zhang S; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: zhangsiyan2016@email.szu.edu.cn.
Jiang Y; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China. Electronic address: jiangyz@szu.edu.cn.

Int J Infect Dis ; 100: 483-489, 2020 Nov.

Article in English | MEDLINE | ID: covidwho-753455

ABSTRACT

ABSTRACT

Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2.

Subject(s)

Antibody-Dependent Enhancement; Betacoronavirus/immunology; Coronavirus Infections/immunology; Pneumonia, Viral/immunology; Betacoronavirus/pathogenicity; COVID-19; Coronavirus Infections/virology; Dengue Virus/immunology; Dengue Virus/pathogenicity; Humans; Middle East Respiratory Syndrome Coronavirus/immunology; Middle East Respiratory Syndrome Coronavirus/pathogenicity; Pandemics; Pneumonia, Viral/virology; SARS-CoV-2; Viral Vaccines/immunology

Keywords

Antibody-dependent enhancement (ADE); Coronavirus disease 2019 (COVID-19); Middle East respiratory syndrome coronavirus (MERS-CoV); Severe acute respiratory syndrome coronavirus (SARS-CoV); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Antibody-Dependent Enhancement / Betacoronavirus Topics: Vaccines Limits: Humans Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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