On the genetics and immunopathogenesis of COVID-19.
Clin Immunol
; 220: 108591, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-753773
ABSTRACT
Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the 'adaptive' immune response to subdue the pathogen by utilizing an adequate 'adaptive' immune defense. Rather it is a consequence of immunopathology, resulting from imbalanced innate immune response, which may not be linked to pathogen burden at all. In fact, it might be described as an autoinflammatory disease. The Kawasaki-like disease seen in children with SARS-CoV-2 exposure might be another example of similar mechanism.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Respiratory Insufficiency
/
Autoimmunity
/
Coronavirus Infections
/
Host-Pathogen Interactions
/
Betacoronavirus
/
Cytokine Release Syndrome
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Immunol
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
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