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On the genetics and immunopathogenesis of COVID-19.
Jacob, Chaim Oscar.
  • Jacob CO; Department of Medicine, Division of Rheumatology and Immunology, Keck School of Medicine, University of Southern California, 2110 Zonal Ave, HMR 705 Los Angeles, CA, USA. Electronic address: Jacob@usc.edu.
Clin Immunol ; 220: 108591, 2020 11.
Article in English | MEDLINE | ID: covidwho-753773
ABSTRACT
Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the 'adaptive' immune response to subdue the pathogen by utilizing an adequate 'adaptive' immune defense. Rather it is a consequence of immunopathology, resulting from imbalanced innate immune response, which may not be linked to pathogen burden at all. In fact, it might be described as an autoinflammatory disease. The Kawasaki-like disease seen in children with SARS-CoV-2 exposure might be another example of similar mechanism.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Insufficiency / Autoimmunity / Coronavirus Infections / Host-Pathogen Interactions / Betacoronavirus / Cytokine Release Syndrome Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Insufficiency / Autoimmunity / Coronavirus Infections / Host-Pathogen Interactions / Betacoronavirus / Cytokine Release Syndrome Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article