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Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
Jeremiah, Sundararaj S; Miyakawa, Kei; Morita, Takeshi; Yamaoka, Yutaro; Ryo, Akihide.
  • Jeremiah SS; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.
  • Miyakawa K; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.
  • Morita T; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.
  • Yamaoka Y; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan; Life Science Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Kanagawa, 259-1146, Japan.
  • Ryo A; Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan. Electronic address: aryo@yokohama-cu.ac.jp.
Biochem Biophys Res Commun ; 533(1): 195-200, 2020 11 26.
Article in English | MEDLINE | ID: covidwho-753910
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus LOCATION_OF colloidal silver
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
colloidal silver
2. Extracellular LOCATION_OF 2019 novel coronavirus
Subject
Extracellular
Predicate
LOCATION_OF
Object
2019 novel coronavirus
3. Assay USES Luciferases
Subject
Assay
Predicate
USES
Object
Luciferases
4. 2019 novel coronavirus LOCATION_OF colloidal silver
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
colloidal silver
5. Extracellular LOCATION_OF 2019 novel coronavirus
Subject
Extracellular
Predicate
LOCATION_OF
Object
2019 novel coronavirus
6. Assay USES Luciferases
Subject
Assay
Predicate
USES
Object
Luciferases
ABSTRACT
The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Pneumonia, Viral / Silver / Coronavirus Infections / Metal Nanoparticles / Betacoronavirus Subject: Antiviral Agents / Pneumonia, Viral / Silver / Coronavirus Infections / Metal Nanoparticles / Betacoronavirus Language: English Journal: Biochem Biophys Res Commun Clinical aspect: Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Antiviral Agents / Pneumonia, Viral / Silver / Coronavirus Infections / Metal Nanoparticles / Betacoronavirus Subject: Antiviral Agents / Pneumonia, Viral / Silver / Coronavirus Infections / Metal Nanoparticles / Betacoronavirus Language: English Journal: Biochem Biophys Res Commun Clinical aspect: Prognosis Year: 2020
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