Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
Biochem Biophys Res Commun
; 533(1): 195-200, 2020 11 26.
Article
in English
| MEDLINE | ID: covidwho-753910
ABSTRACT
The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Silver
/
Coronavirus Infections
/
Metal Nanoparticles
/
Betacoronavirus
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochem Biophys Res Commun
Year:
2020
Document Type:
Article
Affiliation country:
J.bbrc.2020.09.018
Similar
MEDLINE
...
LILACS
LIS