Implications of cellular metabolism for immune cell migration.
Immunology
; 161(3): 200-208, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-755305
ABSTRACT
Cell migration is an essential, energetically demanding process in immunity. Immune cells navigate the body via chemokines and other immune mediators, which are altered under inflammatory conditions of injury or infection. Several factors determine the migratory abilities of different types of immune cells in diverse contexts, including the precise co-ordination of cytoskeletal remodelling, the expression of specific chemokine receptors and integrins, and environmental conditions. In this review, we present an overview of recent advances in our understanding of the relationship of each of these factors with cellular metabolism, with a focus on the spatial organization of glycolysis and mitochondria, reciprocal regulation of chemokine receptors and the influence of environmental changes.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cytoskeleton
/
Cell Movement
/
Inflammation
Limits:
Animals
/
Humans
Language:
English
Journal:
Immunology
Year:
2020
Document Type:
Article
Affiliation country:
Imm.13260
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