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The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues.
Qiao, Jialu; Li, Weiling; Bao, Jian; Peng, Qian; Wen, Dongmei; Wang, Jianing; Sun, Binlian.
  • Qiao J; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Li W; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Bao J; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Peng Q; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.
  • Wen D; School of Life Sciences, Jianghan University, Wuhan, 430056, China.
  • Wang J; School of Life Sciences, Jianghan University, Wuhan, 430056, China.
  • Sun B; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. Electronic address: binlian17@jhun.edu.cn.
Biochem Biophys Res Commun ; 533(4): 867-871, 2020 12 17.
Article in English | MEDLINE | ID: covidwho-756807
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been discovered as the pathogenic cause of the coronavirus disease 19 (COVID-19). Cellular entry of SARS-CoV-2 are mediated by the spike glycoprotein of virus, and the host specific receptors and proteases. Recently, besides pulmonary complications as the chief symptom, investigations have also revealed that SARS-CoV-2 can trigger neurological manifestations. Herein, to investigate the expression level of receptors and related proteases is important for understanding the neuropathy in COVID-19. We determined the expression levels of receptor ACE2 and CD147, and serine protease TMPRSS2 in human and mouse brain cell lines and mouse different region of brain tissues with qRT-PCR and Western blot. The results showed that the expression pattern of all them was very different to that of lung. ACE2 is lower but CD147 is higher expressed in mostly brain cell lines and mouse brain tissues comparing with lung cell line and tissue, and TMPRSS2 has consistent expression in brain cell lines and mouse lung tissues. It is suggested that SARS-CoV-2 might have a different way of infection to cerebral nervous system. Our finding will offer the clues to predict the possibility of SARS-CoV-2 infection to human brain nervous system and pathogenicity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Serine Endopeptidases / Basigin / Receptors, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.09.042

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Serine Endopeptidases / Basigin / Receptors, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Biochem Biophys Res Commun Year: 2020 Document Type: Article Affiliation country: J.bbrc.2020.09.042