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The therapeutic potential of convalescent plasma therapy on treating critically-ill COVID-19 patients residing in respiratory care units in hospitals in Baghdad, Iraq.
Rasheed, Anwar M; Fatak, Dhurgham F; Hashim, Hashim A; Maulood, Mohammed F; Kabah, Khulood K; Almusawi, Yaqoob A; Abdulamir, Ahmed S.
  • Rasheed AM; Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.
  • Fatak DF; Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.
  • Hashim HA; Alkarkh Hospital, Alatefiya, Baghdad, Iraq.
  • Maulood MF; Alforat Hospital, Airport road, Baghdad, Iraq.
  • Kabah KK; Alkharkh General Directorate of Health, Alkadymia, Baghdad, Iraq.
  • Almusawi YA; National Center of Blood Donation, Bab Maadhim, Baghdad, Iraq.
  • Abdulamir AS; College of Medicine, Alnahrain University, Alkadymia, Baghdad, Iraq.
Infez Med ; 28(3): 357-366, 2020 Sep 01.
Article in English | MEDLINE | ID: covidwho-757714
ABSTRACT
The current COVID-19 pandemic needs unconventional therapies to tackle the resulted high morbidity and mortality. Convalescent plasma is one of the therapeutic approaches that might be of benefit. Forty nine early-stage critically-ill COVID-19 patients residing in Respiratory Care Units (RCU) of three hospitals in Baghdad, Iraq, were included 21 received convalescent plasma while 28, namely control group, did not receive it. Recovery or death, length of stay in hospital, and improvement in the clinical course of the disease were monitored clinically along with laboratory monitoring through SARS-CoV-2 RNA detection via PCR, and SARS-CoV-2 IgG and IgM serological monitoring. Patients who received convalescent plasma showed reduced duration of infection in about 4 days and showed less death rate [1/21 versus 8/28 in control group]. In addition, all the patients who were given convalescent plasma showed high levels of SARS-CoV-2 IgG and IgM three days after plasma transfusion. Plasma from donors with high levels of SARS-CoV-2 IgG and donors with positive SRAS-CoV-2 IgM showed better therapeutic results than other donors. Convalescent plasma therapy is an effective therapy if donors with high level of SARS-Cov2 antibodies are selected and if recipients are at their early stage of critical illness, being no more than three days in RCUs.
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Collection: International databases Database: MEDLINE Main subject: Plasma / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Infez Med Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: Iraq

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Collection: International databases Database: MEDLINE Main subject: Plasma / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Infez Med Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: Iraq