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Computational Immune Proteomics Approach to Target COVID-19.
Tilocca, Bruno; Britti, Domenico; Urbani, Andrea; Roncada, Paola.
  • Tilocca B; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro 88100, Italy.
  • Britti D; Department of Health Sciences, University "Magna Graecia" of Catanzaro, Catanzaro 88100, Italy.
  • Urbani A; Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Roma 00168, Italy.
  • Roncada P; Dipartimento di Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli, Roma 00168, Italy.
J Proteome Res ; 19(11): 4233-4241, 2020 11 06.
Article in English | MEDLINE | ID: covidwho-960284
ABSTRACT
Progress of the omics platforms widens their application to diverse fields, including immunology. This enables a deeper level of knowledge and the provision of a huge amount of data for which management and fruitful integration with the past evidence requires a steadily growing computational effort. In light of this, immunoinformatics emerges as a new discipline placed in between the traditional lab-based investigations and the computational analysis of the biological data. Immunoinformatics make use of tailored bioinformatics tools and data repositories to facilitate the analysis of data from a plurality of disciplines and help drive novel research hypotheses and in silico screening investigations in a fast, reliable, and cost-effective manner. Such computational immunoproteomics studies may as well prepare and guide lab-based investigations, representing valuable technology for the investigation of novel pathogens, to tentatively evaluate specificity of diagnostic products, to forecast on potential adverse effects of vaccines and to reduce the use of animal models. The present manuscript provides an overview of the COVID-19 pandemic and reviews the state of the art of the omics technologies employed in fighting SARS-CoV-2 infections. A comprehensive description of the immunoinformatics approaches and its potential role in contrasting COVID-19 pandemics is provided.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Proteomics / Betacoronavirus Type of study: Diagnostic study / Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: Acs.jproteome.0c00553

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Proteomics / Betacoronavirus Type of study: Diagnostic study / Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: Acs.jproteome.0c00553