Biomarker-guided application of low-dose anakinra in an acute respiratory distress syndrome patient with severe COVID-19 and cytokine release syndrome.

Steinhardt, M J; Wiebecke, S; Weismann, D; Frantz, S; Tony, H P; Klinker, H; Schmalzing, M

Steinhardt, M J; Wiebecke, S; Weismann, D; Frantz, S; Tony, H P; Klinker, H; Schmalzing, M.

Steinhardt MJ; Department of Internal Medicine II, University Hospital Würzburg , Würzburg, Germany.
Wiebecke S; Department of Internal Medicine II, University Hospital Würzburg , Würzburg, Germany.
Weismann D; Department of Internal Medicine I, University Hospital Würzburg , Würzburg, Germany.
Frantz S; Department of Internal Medicine I, University Hospital Würzburg , Würzburg, Germany.
Tony HP; Department of Internal Medicine II, University Hospital Würzburg , Würzburg, Germany.
Klinker H; Department of Internal Medicine II, University Hospital Würzburg , Würzburg, Germany.
Schmalzing M; Department of Internal Medicine II, University Hospital Würzburg , Würzburg, Germany.

Scand J Rheumatol ; 49(5): 414-416, 2020 09.

Article in English | MEDLINE | ID: covidwho-759718

Subject(s)

Coronavirus Infections; Cytokine Release Syndrome; Interleukin 1 Receptor Antagonist Protein/administration & dosage; Interleukin-6/blood; Pandemics; Pneumonia, Viral; Antirheumatic Agents/administration & dosage; Betacoronavirus/isolation & purification; Biomarkers, Pharmacological; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/physiopathology; Coronavirus Infections/therapy; Cytokine Release Syndrome/blood; Cytokine Release Syndrome/diagnosis; Cytokine Release Syndrome/drug therapy; Cytokine Release Syndrome/etiology; Dose-Response Relationship, Drug; Drug Monitoring/methods; Ferritins/blood; Humans; Lactate Dehydrogenases/blood; Male; Middle Aged; Pneumonia, Viral/immunology; Pneumonia, Viral/physiopathology; Pneumonia, Viral/therapy; Respiration, Artificial/methods; SARS-CoV-2; Severity of Illness Index; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections / Interleukin 1 Receptor Antagonist Protein / Pandemics / Cytokine Release Syndrome Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: Scand J Rheumatol Year: 2020 Document Type: Article Affiliation country: 03009742.2020.1789734

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