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Diagnostic approaches in COVID-19: clinical updates.
Asrani, Purva; Eapen, Mathew Suji; Chia, Collin; Haug, Greg; Weber, Heinrich C; Hassan, Md Imtaiyaz; Sohal, Sukhwinder Singh.
  • Asrani P; Division of Biochemistry, Indian Agricultural Research Institute , New Delhi, India.
  • Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania , Launceston, Australia.
  • Chia C; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania , Launceston, Australia.
  • Haug G; Department of Respiratory Medicine, Launceston General Hospital , Launceston, Australia.
  • Weber HC; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania , Launceston, Australia.
  • Hassan MI; Department of Respiratory Medicine, Launceston General Hospital , Launceston, Australia.
  • Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania , Launceston, Australia.
Expert Rev Respir Med ; 15(2): 197-212, 2021 02.
Article in English | MEDLINE | ID: covidwho-759841
ABSTRACT

INTRODUCTION:

COVID-19 is a recent emerging pandemic whose prognosis is still unclear. Diagnostic tools are the main players that not only indicate a possible infection but can further restrict the transmission and can determine the extent to which disease progression would occur. AREAS COVERED In this paper, we have performed a narrative and critical review on different technology-based diagnostic strategies such as molecular approaches including real-time reverse transcriptase PCR, serological testing through enzyme-linked immunosorbent assay, laboratory and point of care devices, radiology-based detection through computed tomography and chest X-ray, and viral cell cultures on Vero E6 cell lines are discussed in detail to address COVID-19. This review further provides an overview of emergency use authorized immunodiagnostic and molecular diagnostic kits and POC devices by FDA for timely and efficient conduction of diagnostic tests. The majority of the literature cited in this paper is collected from guidelines on protocols and other considerations on diagnostic strategies of COVID-19 issued by WHO, CDC, and FDA under emergency authorization. EXPERT OPINION Such information holds importance to the health professionals in conducting error-free diagnostic tests and researches in producing better clinical strategies by addressing the limitations associated with the available methods.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study / Qualitative research / Reviews Limits: Animals / Humans Language: English Journal: Expert Rev Respir Med Year: 2021 Document Type: Article Affiliation country: 17476348.2021.1823833

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Prognostic study / Qualitative research / Reviews Limits: Animals / Humans Language: English Journal: Expert Rev Respir Med Year: 2021 Document Type: Article Affiliation country: 17476348.2021.1823833