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COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel.
Napodano, Cecilia; Pocino, Krizia; Stefanile, Annunziata; Marino, Mariapaola; Miele, Luca; Gulli, Francesca; Basile, Valerio; Pandolfi, Franco; Gasbarrini, Antonio; Rapaccini, Gian Ludovico; Basile, Umberto.
  • Napodano C; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Pocino K; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Stefanile A; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Marino M; Dipartimento di Medicina e Chirurgia Traslazionale, Istituto di Patologia generale, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Miele L; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Gulli F; Dipartimento di Medicina di Laboratorio, Ospedale Madre Giuseppina Vannini, Rome, Italy.
  • Basile V; Dipartimento di Medicina di Laboratorio, Università degli Studi di Roma "Tor Vergata", Rome, Italy.
  • Pandolfi F; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Gasbarrini A; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Rapaccini GL; Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
  • Basile U; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario "A. Gemelli" I.R.C.C.S, Rome, Italy.
Scand J Immunol ; 93(3): e12977, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-760191
ABSTRACT
In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Liver / Liver Diseases Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Scand J Immunol Year: 2021 Document Type: Article Affiliation country: Sji.12977

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Liver / Liver Diseases Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Scand J Immunol Year: 2021 Document Type: Article Affiliation country: Sji.12977