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SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study.
Shields, Adrian; Faustini, Sian E; Perez-Toledo, Marisol; Jossi, Sian; Aldera, Erin; Allen, Joel D; Al-Taei, Saly; Backhouse, Claire; Bosworth, Andrew; Dunbar, Lyndsey A; Ebanks, Daniel; Emmanuel, Beena; Garvey, Mark; Gray, Joanna; Kidd, I Michael; McGinnell, Golaleh; McLoughlin, Dee E; Morley, Gabriella; O'Neill, Joanna; Papakonstantinou, Danai; Pickles, Oliver; Poxon, Charlotte; Richter, Megan; Walker, Eloise M; Wanigasooriya, Kasun; Watanabe, Yasunori; Whalley, Celina; Zielinska, Agnieszka E; Crispin, Max; Wraith, David C; Beggs, Andrew D; Cunningham, Adam F; Drayson, Mark T; Richter, Alex G.
  • Shields A; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Faustini SE; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Perez-Toledo M; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Jossi S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Aldera E; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Allen JD; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Al-Taei S; School of Biological Sciences, University of Southampton, Southampton, UK.
  • Backhouse C; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Bosworth A; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Dunbar LA; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Ebanks D; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Emmanuel B; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Garvey M; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Gray J; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Kidd IM; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • McGinnell G; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • McLoughlin DE; Public Health England Midlands and East Region, Birmingham, UK.
  • Morley G; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • O'Neill J; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
  • Papakonstantinou D; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
  • Pickles O; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Poxon C; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Richter M; Surgical Research Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Walker EM; Surgical Research Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Wanigasooriya K; Clinical Immunology Service, University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.
  • Watanabe Y; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Whalley C; Surgical Research Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Zielinska AE; School of Biological Sciences, University of Southampton, Southampton, UK.
  • Crispin M; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK.
  • Wraith DC; Surgical Research Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Beggs AD; Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Cunningham AF; School of Biological Sciences, University of Southampton, Southampton, UK.
  • Drayson MT; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Richter AG; University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, NIHR Biomedical Research Centre, Birmingham, UK.
Thorax ; 75(12): 1089-1094, 2020 12.
Article in English | MEDLINE | ID: covidwho-760280
ABSTRACT

OBJECTIVE:

To determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.

DESIGN:

A cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.

SETTING:

University Hospitals Birmingham NHS Foundation Trust (UHBFT), UK.

PARTICIPANTS:

545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded. INTERVENTION Participants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked. MAIN OUTCOME

MEASURE:

Proportion of participants demonstrating infection and positive SARS-CoV-2 serology.

RESULTS:

The point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ2=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR 0.28, 95% CI 0.09 to 0.78, p=0.02). CONCLUSIONS AND RELEVANCE We identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Asymptomatic Diseases / Pandemics / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Thorax Year: 2020 Document Type: Article Affiliation country: Thoraxjnl-2020-215414

Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / Asymptomatic Diseases / Pandemics / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prevalence study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Thorax Year: 2020 Document Type: Article Affiliation country: Thoraxjnl-2020-215414