Predictive factors of progression to severe COVID-19.
Open Med (Wars)
; 15(1): 805-814, 2020.
Article
in English
| MEDLINE | ID: covidwho-760726
ABSTRACT
AIM:
Early diagnosis and treatment are crucial for the survival of severe Coronavirus Disease 2019 (COVID-19) patients, but data with regard to risk factors for disease progression from milder COVID-19 to severe COVID-19 remain scarce.METHODS:
We conducted a retrospective analysis on 116 patients.RESULTS:
Three factors were observed to be independently associated with progression to severe COVID-19 during 14 days after admission (a) age 65 years or older (hazard ratio [HR] = 8.456; 95% CI 2.706-26.426); (b) creatine kinase (CK) ≥ 180 U/L (HR = 3.667; 95% CI 1.253-10.733); and (c) CD4+ T-cell counts <300 cells/µL (HR = 4.695; 95% CI 1.483-14.856). The difference in rates of severe COVID-19 development was found to be statistically significant between patients aged 65 years or older (46.2%) and those younger than 65 years (90.2%), between patients with CK ≥ 180 U/L (55.6%) and those with CK < 180 U/L (91.5%), and between patients with CD4+ T-cell counts <300 cells/µL (53.8%) and those with CD4+ cell counts ≥300 cells/µL (83.2%).CONCLUSIONS:
Age ≥ 65 years, CK ≥ 180 U/L, and CD4+ T-cell counts <300 cells/µL at admission were risk factors independently associated with disease progression to severe COVID-19 during 14 days after admission and are therefore potential markers for disease progression in patients with milder COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Open Med (Wars)
Year:
2020
Document Type:
Article
Affiliation country:
Med-2020-0184
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