Your browser doesn't support javascript.
[Acro-ischemic injuries in children-adolescents during CoViD-19 pandemic: from lifestyle changes due to lockdown to interferone.] / Le lesioni acro-ischemiche nei bambini-adolescenti in tempi di CoViD-19: dal micro-ambiente da clausura all'interferone.
Marchetti, Federico; Guiducci, Claudia; Bigucci, Barbara; Iacono, Alessandra; Calderoni, Ombretta; Sorci, Maria Rita; Sparacino, Monica; Semprini, Simona; Vergine, Gianluca.
  • Marchetti F; UOC di Pediatria e Neonatologia, Ospedale di Ravenna.
  • Guiducci C; UOC di Pediatria e Neonatologia, Ospedale di Ravenna - Scuola di Specializzazione in Pediatria, Università di Ferrara.
  • Bigucci B; UOC di Pediatria, Ospedale di Rimini.
  • Iacono A; UOC di Pediatria e Neonatologia, Ospedale di Ravenna.
  • Calderoni O; UO di Dermatologia, Ospedale di Ravenna.
  • Sorci MR; UO di Dermatologia, Ospedale di Rimini.
  • Sparacino M; UO Microbiologia, Laboratorio Unico, AUSL della Romagna.
  • Semprini S; UO Microbiologia, Laboratorio Unico, AUSL della Romagna.
  • Vergine G; UOC di Pediatria, Ospedale di Rimini.
Recenti Prog Med ; 111(9): 480-486, 2020 09.
Article in Italian | MEDLINE | ID: covidwho-760767
ABSTRACT
At the end of March 2020, just over a month after the first ascertained case of CoViD-19 infection in Italy, the first reports of acute lesions of acro-ischemia appeared, especially in pre-adolescents and adolescents. These manifestations have been called in the course of these months in various ways, from "acro-ischemia acuta", "erythema pernio", "chilblains", up to characterize them more recently as "CoViD Toes". Clinical manifestations do not usually associate with other typical symptoms of Covid-19 and do not find a classical and defined serological antibody response (IgG and IgM). From a clinical point of view it is a localized and self-resolving problem of an interesting and relatively new pathogenetic model of disease in relation to a viral agent. Future studies must make us understand if there is in this specific condition a low viral load is not detectable by current methods and if this explains the inability to produce an adequate immune response for CoViD-19. It is important to determine whether the interferon immune response in some subjects can be the cause of both the low viremia and the endothelial damage so localized in the acral-site, as happens in other models of diseases (chilblain-lupus like). On the contrary, some authors believe that the acral lesions are attributable to chilblains caused by a series of favourable environmental conditions due to forced enclosure. We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents observed in the territorial area of Ravenna and Rimini. The cases were subjected to the nasopharyngeal swab and to the search for antibodies with ELISA method for CoViD-19 both with negative results.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interferons / Coronavirus Infections / Ischemia / Life Style Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Female / Humans / Male Country/Region as subject: Europa Language: Italian Journal: Recenti Prog Med Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interferons / Coronavirus Infections / Ischemia / Life Style Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Child / Female / Humans / Male Country/Region as subject: Europa Language: Italian Journal: Recenti Prog Med Year: 2020 Document Type: Article