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Self-Collected versus Healthcare Worker-Collected Swabs in the Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2.
Therchilsen, Johan H; von Buchwald, Christian; Koch, Anders; Dam Nielsen, Susanne; Rasmussen, Daniel B; Thudium, Rebekka Faber; Kirkby, Nikolai S; Raaschou-Pedersen, Daniel E T; Bundgaard, Johan S; Iversen, Kasper; Bundgaard, Henning; Todsen, Tobias.
  • Therchilsen JH; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Koch A; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Dam Nielsen S; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Rasmussen DB; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Thudium RF; Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Kirkby NS; Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Raaschou-Pedersen DET; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Bundgaard JS; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Iversen K; Department of Cardiology, Copenhagen University Hospital Herlev, 2730 Herlev, Denmark.
  • Bundgaard H; Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
  • Todsen T; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Diagnostics (Basel) ; 10(9)2020 Sep 09.
Article in English | MEDLINE | ID: covidwho-760895
ABSTRACT
The aim of this study was to compare the sensitivity of self-collected versus healthcare worker (HCW)-collected swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. Symptomatic individuals referred for SARS-CoV-2 testing were invited to provide mobile-phone video-instructed self-collected oropharyngeal and nasal samples followed by a HCW-collected oropharyngeal sample. All samples were sent for analysis to the same microbiology laboratory, and the number of SARS-CoV-2-positive participants in the two tests was compared. A total of 109 participants were included, and 19 participants had SARS-CoV-2-positive results. The diagnostic sensitivity of the self-collected and HCW-collected swabs was 84.2% and 89.5%, respectively, with an acceptable agreement, Cohens kappa 0.82, p < 0.001. Further, results from a questionnaire answered by the participants found that loss of smell as a self-reported symptom was a strong predictor for a SARS-CoV-2-positive test. In conclusion, we found that self-collected oropharyngeal and nasal swabs for SARS-CoV-2 testing can be reliable compared to HCW-collected oropharyngeal samples.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Year: 2020 Document Type: Article Affiliation country: Diagnostics10090678

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Language: English Year: 2020 Document Type: Article Affiliation country: Diagnostics10090678