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[A single arm clinical study of 86 patients with common type of coronavirus disease 2019 treated by integrated traditional Chinese and Western medicine: multicenter case observation from 7 designated hospitals in Henan Province].
Xie, Yang; Wang, Jiajia; Li, Suyun; Fu, Lili; Sun, Jie; Zhao, Jinling; Zhang, Huaru; Jia, Kui; Zhao, Qingxia; Li, Bin; Li, Jiansheng.
  • Xie Y; Department of Respiratory Diseases, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China.
  • Wang J; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.
  • Li S; Department of Respiratory Diseases, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China.
  • Fu L; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.
  • Sun J; Department of Respiratory Diseases, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China.
  • Zhao J; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan and Education Ministry of P. R. China/Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China.
  • Zhang H; Department of Traditional Chinese Medicine, Nanyang Central Hospital, Nanyang 473000, Henan, China.
  • Jia K; Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanyang Medical College, Nanyang 473058, Henan, China.
  • Zhao Q; Department of Cardiovascular Diseases, Jiaozuo Hospital of Traditional Chinese Medicine, Jiaozuo 454000, Henan, China.
  • Li B; Department of Respiratory Diseases, Zhumadian Central Hospital, Zhumadian 463300, Henan, China.
  • Li J; Department of Integrated Traditional Chinese and Western Medicine, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan, China.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(8): 922-927, 2020 Aug.
Article in Chinese | MEDLINE | ID: covidwho-760965
ABSTRACT

OBJECTIVE:

To evaluate the clinical effect of integrated traditional Chinese and Western medicine on common type of coronavirus disease 2019 (COVID-19) in Henan Province.

METHODS:

A prospective single arm clinical study was performed. Patients with common type of COVID-19 admitted to seven designated hospitals for COVID-19 in Henan Province from January 25th to February 26th, 2020 were enrolled, and treated with integrated traditional Chinese and Western medicine. The negative transformation of 2019 novel coronavirus (2019-nCoV) nucleic acid, disease outcome, hospital stay, clinical symptoms and signs scores, and chest imaging performance were observed.

RESULTS:

Totally 86 cases were included in the analysis, including 48 males (55.8%), aged 43.5 (35.0, 53.3) years old, 24 patients (27.9%) with previous medical history. Fifty-eight patients were primarily diagnosed COVID-19 and 28 patients were transferred. The 2019-nCoV nucleic acid of 86 cases (100%) turned negative, and the median time of turning negative was 10 (7, 14) days. Eighty-six cases (100%) were discharged from hospital, and none turned into the severe type; the average length of hospital stay was (13.8±5.6) days. The scores of fever, cough, chest tightness, shortness of breath, and fatigue decreased with the treatment time, and the scores of 7 days and 14 days after treatment were significantly lower than those before treatment [fever (points) 0 (0, 0), 0 (0, 0) vs. 1 (0, 1); cough (points) 1 (0, 1), 0 (0, 1) vs. 1 (0, 2); chest tightness (points) 0 (0, 0), 0 (0, 0) vs. 0 (0, 1); shortness of breath (points) 0 (0, 0), 0 (0, 0) vs. 0 (0, 1); fatigue (points) 0 (0, 1), 0 (0, 1) vs. 1 (0, 1); all P < 0.05]. The improvement rate of X ray and CT image was 42.9% (12/28) and 81.0% (64/79), respectively.

CONCLUSIONS:

The treatment with integrated traditional Chinese and Western medicine has good curative effect on common type of COVID-19 in 7 designated hospitals of Henan Province. It can improve the clinical symptoms, promote the absorption of pulmonary inflammation, and to some extent control the progress of disease and shorten the time of turning negative of virus nucleic acid and hospital stay.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Integrative Medicine / Medicine, Chinese Traditional Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Traditional medicine Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article Affiliation country: Cma.j.cn121430-20200528-00485

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Integrative Medicine / Medicine, Chinese Traditional Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Traditional medicine Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: Chinese Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue Year: 2020 Document Type: Article Affiliation country: Cma.j.cn121430-20200528-00485