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Clinical characteristics of 3062 COVID-19 patients: A meta-analysis.
Zhu, Jieyun; Ji, Pan; Pang, Jielong; Zhong, Zhimei; Li, Hongyuan; He, Cuiying; Zhang, Jianfeng; Zhao, Chunling.
  • Zhu J; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Ji P; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Pang J; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Zhong Z; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Li H; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • He C; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Zhang J; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
  • Zhao C; Department of Emergency, The Second Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic China.
J Med Virol ; 92(10): 1902-1914, 2020 10.
Article in English | MEDLINE | ID: covidwho-763159
ABSTRACT
We aimed to systematically review the clinical characteristics of coronavirus disease 2019 (COVID-19). Seven databases were searched to collect studies about the clinical characteristics of COVID-19 from January 1, 2020 to February 28, 2020. Then, meta-analysis was performed by using Stata12.0 software. A total of 38 studies involving 3062 COVID-19 patients were included. Meta-analysis showed that a higher proportion of infected patients was male (56.9%). The incidence rate of respiratory failure or acute respiratory distress syndrome was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%), and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia (13.1%), shivering (10.9%), and abdominal pain (4.4%). The proportion of patients that was asymptomatic was 11.9%. Normal leukocyte counts (69.7%), lymphopenia (56.5%), elevated C-reactive protein levels (73.6%), elevated ESR (65.6%), and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients were found with elevated D-dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%), and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving a single lung and 75.7% of patients had lesions involving bilateral lungs. The most commonly experienced symptoms of COVID-19 patients were fever, fatigue, cough, and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C-reactive protein and ESR. Bilateral lung involvement was common.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Language: English Journal: J Med Virol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Reviews Language: English Journal: J Med Virol Year: 2020 Document Type: Article