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Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID-19 patients.
Ding, Hong; Deng, Wenjun; Ding, Lingling; Ye, Xiaoqun; Yin, Shanye; Huang, Weishan.
  • Ding H; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
  • Deng W; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Ding L; Department of anatomy, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Ye X; Department of Respiratory Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Yin S; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
  • Huang W; Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
J Med Virol ; 92(10): 2200-2204, 2020 10.
Article in English | MEDLINE | ID: covidwho-763196
ABSTRACT
SARS-CoV-2 is highly infectious, and infection by this virus results in COVID-19, manifesting predominantly symptoms in the lower respiratory system. Detection of viral genomic materials by RT-PCR is the gold standard for diagnosis. Suspected COVID-19 patients who had a documented history of exposure and exhibited symptoms, but did not have positive PCR test results, were generally self-quarantined with prescriptions aiming to help attenuate their symptoms. These prescriptions are however neither specific nor highly effective for COVID-19 treatment. Given the rapidly growing pandemic and the overwhelmed medical system, the number of self-quarantined patients is increasing. There is an urgent need of alternative medicine to help patients relieve symptoms during self-quarantine, and to potentially help increase their chances of survival and recovery from the infection. We report here a case of severe COVID-19 that never had a positive PCR test result during disease progression but was confirmed with antibody test post recovery. This patient was self-quarantined and received diammonium glycyrrhizinate (DG), a steroid-like molecule, in combination with vitamin C as alternative medicine. This patient went through severe COVID-19 but eventually recovered upon the implementation of this treatment regimen, suggesting potential therapeutic effects of DG as alternative medicine to help relieve COVID-19 symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Glycyrrhetinic Acid Type of study: Case report / Prognostic study Topics: Traditional medicine Limits: Female / Humans / Middle aged Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26064

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Glycyrrhetinic Acid Type of study: Case report / Prognostic study Topics: Traditional medicine Limits: Female / Humans / Middle aged Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26064