Risk of severe coronavirus disease in imported and secondary cases in Zhejiang province, China.
J Public Health (Oxf)
; 43(1): 35-41, 2021 04 12.
Article
in English
| MEDLINE | ID: covidwho-766756
ABSTRACT
BACKGROUND:
To our knowledge, no previous studies have focused on determining whether the virulence and case fatality rate of the severe acute respiratory coronavirus 2 (SARS-CoV-2) decreases as the virus continues to spread. Hence, our aim was to retrospectively explore the differences in the risk of severe or critical COVID-19 among imported, secondary and tertiary cases in Zhejiang, China.METHODS:
We categorized COVID-19 cases reported by hospitals in Zhejiang as first-, second- and third-generation cases. Univariate and multivariate logistic regression analyses were performed to compare disease severity and case generation.RESULTS:
Of 1187 COVID-19 cases, 227 (19.1%, 95% CI 16.9-21.4) manifested severe or critical illness. The adjusted risk difference for severe or critical illness was lower for second- (odds ratio (OR) = 0.84, 95% confidence interval (CI) 0.52-1.36) and third-generation (OR = 0.55, 95% CI 0.37-0.83) cases than for first-generation cases. Compared with hospitalized patients, cases identified at centralized isolation locations (OR = 0.62, 95% CI 0.40-0.97) and those identified through active search or gateway screening (OR = 0.28, 95% CI 0.08-1.04) were at a lower risk of severe or critical illness.CONCLUSIONS:
Second- and third-generation cases of COVID-19 have a lower risk of developing severe or critical illness than first-generation cases.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
J Public Health (Oxf)
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS