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Coronavirus Disease 2019 versus Influenza A in Children: An Observational Control Study in China.
Zhao, Yang; Sun, De Lin; Bouchard, Heather C; Zhang, Xin Xin; Wan, Gang; Hao, Yi Wei; He, Shu Xin; Jiang, Yu Yong; Pang, Lin.
  • Zhao Y; Department of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Sun L; Brain Imaging and Analysis Center, Duke University, Durham 20075, North Carolina, USA.
  • Bouchard HC; Brain Imaging and Analysis Center, Duke University, Durham 20075, North Carolina, USA.
  • Zhang XX; Department of Party Committee, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Wan G; Department of Medical Records, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Hao YW; Department of Medical Records, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • He SX; Department of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Jiang YY; Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • Pang L; Department of Pediatrics, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Biomed Environ Sci ; 33(8): 614-619, 2020 Aug 20.
Article in English | MEDLINE | ID: covidwho-771380
ABSTRACT
This study aimed to understand the differences in clinical, epidemiological, and laboratory features between the new coronavirus disease 2019 (COVID-2019) and influenza A in children. Data of 23 hospitalized children with COVID-19 (9 boys, 5.7 ± 3.8 years old) were compared with age- and sex-matched 69 hospitalized and 69 outpatient children with influenza A from a hospital in China. The participants' epidemiological history, family cluster, clinical manifestations, and blood test results were assessed. Compared with either inpatients or outpatients with influenza A, children with COVID-19 showed significantly more frequent family infections and higher ratio of low fever (< 37.3 °C), but shorter cough and fever duration, lower body temperature, and lower rates of cough, fever, high fever (> 39 °C), nasal congestion, rhinorrhea, sore throat, vomiting, myalgia or arthralgia, and febrile seizures. They also showed higher counts of lymphocytes, T lymphocyte CD8, and platelets and levels of cholinesterase, aspartate aminotransferase, lactate dehydrogenase, and lactic acid, but lower serum amyloid, C-reactive protein, and fibrinogen levels and erythrocyte sedimentation rate, and shorter prothrombin time. The level of alanine aminotransferase in children with COVID-19 is lower than that in inpatients but higher than that in outpatients with influenza A. Pediatric COVID-19 is associated with more frequent family infection, milder symptoms, and milder immune responses relative to pediatric influenza A.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Influenza, Human / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: Biomed Environ Sci Journal subject: Environmental Health Year: 2020 Document Type: Article Affiliation country: Bes2020.080

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Influenza, Human / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: Biomed Environ Sci Journal subject: Environmental Health Year: 2020 Document Type: Article Affiliation country: Bes2020.080