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Characteristics of immune cells and cytokines in patients with coronavirus disease 2019 in Guangzhou, China.
Chen, Xing; Huang, Jide; Huang, Ying; Chen, Jiabin; Huang, Yingyi; Jiang, Xiaowen; Shi, Yaling.
  • Chen X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Huang J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Huang Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Chen J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Huang Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Jiang X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China.
  • Shi Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Dexing Erheng Road, Baiyun District, Guangzhou, Guangdong Province 510000, China. Electronic address: gz8hsyl@126.com.
Hum Immunol ; 81(12): 702-708, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-773666
ABSTRACT
To discover immune factors that can predict the progression of COVID-19, we evaluated circulating immune cells and plasma cytokines in COVID-19 patients. We found that T cells, including CD4+ T cells and CD8+ T cells, were significantly decreased in severe COVID-19 symptoms but not in mild symptoms, in comparison with healthy people. T cells remained at a low level after recovery from severe COVID-19. CD4+CD25+CD127low Treg-enriched cells were significantly increased in either mild or severe COVID-19 patients, regardless of recovery or not. Moreover, in either mild or severe COVID-19 patients, Treg-enriched cells up-regulated CD25 and down-regulated CD127. After recovery, CD25 was partially down-regulated but still higher than the normal level, while CD127 returned to the normal level in mild patients but not severe patients. B cells were decreased in mild patients and further decreased in severe patients, and remained low after recovery. NK cells were decreased only in severe COVID-19, with a tendency to return to the normal level after recovery. Plasma IL-6 and IL-10 were both elevated in severe patients but not in mild patients. After recovery, IL-6 remained higher than its normal level, while IL-10 returned to the normal level. Binary logistic regression analysis indicated that CD4+ T cells, B cells, IL-6, and IL-10 were significantly associated with COVID-19 severity. Therefore, these parameters are indicators of COVID-19 severity. Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Killer Cells, Natural / Interleukin-6 / Interleukin-10 / T-Lymphocytes, Regulatory / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Hum Immunol Year: 2020 Document Type: Article Affiliation country: J.humimm.2020.08.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / Killer Cells, Natural / Interleukin-6 / Interleukin-10 / T-Lymphocytes, Regulatory / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Hum Immunol Year: 2020 Document Type: Article Affiliation country: J.humimm.2020.08.006