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A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2 infection.
Masuccio, Fabio Giuseppe; Barra, Massimo; Claudio, Geda; Claudio, Solaro.
  • Masuccio FG; Department of Neurorehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, SNC, 13040, Moncrivello, VC, Italy. fgmasuccio@yahoo.it.
  • Barra M; Department of Neurology, ASL TO4 Chivasso, C.so G. Ferraris 3, Chivasso, Italy.
  • Claudio G; Department of Neurology, ASL TO4 Ivrea, P.za Credenza 2, Ivrea, Italy.
  • Claudio S; Department of Neurorehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone, SNC, 13040, Moncrivello, VC, Italy.
J Neurol ; 268(7): 2327-2330, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-774340
ABSTRACT
We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barrè Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with "ground glass opacities", suggesting Coronavirus disease (COVID-19). The patient exhibited three negative reverse-transcription polymerase chain reaction (RT-PCR) nasopharyngeal swabs, while SARS-CoV-2 IgG was found in plasma. The electrophysiological examination demonstrated an AMAN and the spinal cord Magnetic Resonance Imaging (MRI) showed a T2-weighted hyperintense lesion in the posterior part of the spinal cord at the C7-D1 levels. Furthermore, anti-GD1b IgM was detected. GBS and myelitis could exceptionally develop simultaneously. Our findings reasonably support a causality link between COVID-19 and the neurological symptoms, suggesting a post-infective autoimmune reaction.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 / Myelitis Type of study: Case report / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-020-10219-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 / Myelitis Type of study: Case report / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-020-10219-5