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Targeting RNA G-Quadruplex in SARS-CoV-2: A Promising Therapeutic Target for COVID-19?
Zhao, Chuanqi; Qin, Geng; Niu, Jingsheng; Wang, Zhao; Wang, Chunyu; Ren, Jinsong; Qu, Xiaogang.
  • Zhao C; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
  • Qin G; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
  • Niu J; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
  • Wang Z; University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
  • Wang C; Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
  • Ren J; University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
  • Qu X; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, P. R. China.
Angew Chem Int Ed Engl ; 60(1): 432-438, 2021 01 04.
Article in English | MEDLINE | ID: covidwho-774564
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus LOCATION_OF G-Quadruplexes
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
G-Quadruplexes
2. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
3. 2019 novel coronavirus LOCATION_OF DNA Sequence
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
DNA Sequence
4. Phosphoproteins PART_OF Nucleocapsid
Subject
Phosphoproteins
Predicate
PART_OF
Object
Nucleocapsid
5. 2019 novel coronavirus LOCATION_OF G-Quadruplexes
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
G-Quadruplexes
6. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
7. 2019 novel coronavirus LOCATION_OF DNA Sequence
Subject
2019 novel coronavirus
Predicate
LOCATION_OF
Object
DNA Sequence
8. Phosphoproteins PART_OF Nucleocapsid
Subject
Phosphoproteins
Predicate
PART_OF
Object
Nucleocapsid
ABSTRACT
The COVID-19 pandemic caused by SARS-CoV-2 has become a global threat. Understanding the underlying mechanisms and developing innovative treatments are extremely urgent. G-quadruplexes (G4s) are important noncanonical nucleic acid structures with distinct biofunctions. Four putative G4-forming sequences (PQSs) in the SARS-CoV-2 genome were studied. One of them (RG-1), which locates in the coding sequence region of SARS-CoV-2 nucleocapsid phosphoprotein (N), has been verified to form a stable RNA G4 structure in live cells. G4-specific compounds, such as PDP (pyridostatin derivative), can stabilize RG-1 G4 and significantly reduce the protein levels of SARS-CoV-2 N by inhibiting its translation both in vitro and in vivo. This result is the first evidence that PQSs in SARS-CoV-2 can form G4 structures in live cells, and that their biofunctions can be regulated by a G4-specific stabilizer. This finding will provide new insights into developing novel antiviral drugs against COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / RNA, Viral / G-Quadruplexes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Angew Chem Int Ed Engl Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / RNA, Viral / G-Quadruplexes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Traditional medicine Limits: Humans Language: English Journal: Angew Chem Int Ed Engl Year: 2021 Document Type: Article