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Seizure in patients with COVID-19.
Emami, Amir; Fadakar, Nima; Akbari, Ali; Lotfi, Mehrzad; Farazdaghi, Mohsen; Javanmardi, Fatemeh; Rezaei, Tahereh; Asadi-Pooya, Ali A.
  • Emami A; Burn & Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Fadakar N; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Akbari A; Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Lotfi M; Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Farazdaghi M; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Javanmardi F; Burn & Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Rezaei T; Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Asadi-Pooya AA; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. aliasadipooya@yahoo.com.
Neurol Sci ; 41(11): 3057-3061, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-777864
Semantic information from SemMedBD (by NLM)
1. Seizures PROCESS_OF Patients
Subject
Seizures
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
4. Seizures PROCESS_OF Persons
Subject
Seizures
Predicate
PROCESS_OF
Object
Persons
5. Status Epilepticus PROCESS_OF Patients
Subject
Status Epilepticus
Predicate
PROCESS_OF
Object
Patients
6. Hypoxemia PROCESS_OF Patients
Subject
Hypoxemia
Predicate
PROCESS_OF
Object
Patients
7. Metabolic Diseases PROCESS_OF Patients
Subject
Metabolic Diseases
Predicate
PROCESS_OF
Object
Patients
8. Abnormal PROCESS_OF Patients
Subject
Abnormal
Predicate
PROCESS_OF
Object
Patients
9. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
10. seizure new onset PROCESS_OF Patients
Subject
seizure new onset
Predicate
PROCESS_OF
Object
Patients
11. Seizures PROCESS_OF Patients
Subject
Seizures
Predicate
PROCESS_OF
Object
Patients
12. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
14. Seizures PROCESS_OF Persons
Subject
Seizures
Predicate
PROCESS_OF
Object
Persons
15. Status Epilepticus PROCESS_OF Patients
Subject
Status Epilepticus
Predicate
PROCESS_OF
Object
Patients
16. Hypoxemia PROCESS_OF Patients
Subject
Hypoxemia
Predicate
PROCESS_OF
Object
Patients
17. Metabolic Diseases PROCESS_OF Patients
Subject
Metabolic Diseases
Predicate
PROCESS_OF
Object
Patients
18. Abnormal PROCESS_OF Patients
Subject
Abnormal
Predicate
PROCESS_OF
Object
Patients
19. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
20. seizure new onset PROCESS_OF Patients
Subject
seizure new onset
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

OBJECTIVE:

The purpose of the current study was to collect the data on the occurrence of seizures in patients with COVID-19 and to clarify the circumstances of the occurrence of seizures in these patients.

METHODS:

All consecutive patients who referred to healthcare facilities anywhere in Fars province (located in South Iran with a population of 4.851 million people) from February 19 until June 2, 2020, and had confirmed COVID-19 by positive result on polymerase chain reaction testing and seizure were included.

RESULTS:

During the study period, 6,147 people had confirmed COVID-19 in Fars province, Iran; 110 people died from the illness (case fatality rate 1.79%). During this time period, five people had seizures (seizure rate 0.08%). In four patients, seizure was one of the presenting manifestations, and in one person, it happened during the course of hospital admission. Two patients had status epilepticus. All patients experienced hypoxemia and four of them needed respirator. Two patients had related metabolic derangements and one had cerebrospinal fluid (CSF) lymphocytic pleocytosis. Brain imaging was abnormal in three patients. Four patients died.

CONCLUSION:

New-onset seizures in critically ill patients with COVID-19 should be considered as acute symptomatic seizures and the treating physician should try to determine the etiology of the seizure and manage the cause immediately and appropriately. Detailed clinical, neurological, imaging, and electrophysiological investigations and attempts to isolate SARS-CoV-2 from CSF may clarify the role played by this virus in causing seizures in these patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Seizures / Coronavirus Infections Limits: Adult / Child, preschool / Female / Humans / Male / Middle aged / Infant, Newborn Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: S10072-020-04731-9

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Seizures / Coronavirus Infections Limits: Adult / Child, preschool / Female / Humans / Male / Middle aged / Infant, Newborn Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: S10072-020-04731-9