Thyroid disorders and SARS-CoV-2 infection: From pathophysiological mechanism to patient management.

Caron, Philippe

Caron, Philippe.

Caron P; Service d'endocrinologie et maladies métaboliques, pôle cardiovasculaire et métabolique, CHU Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse cedex, France. Electronic address: caron.p@chu-toulouse.fr.

Ann Endocrinol (Paris) ; 81(5): 507-510, 2020 Oct.

Article in English | MEDLINE | ID: covidwho-778380

ABSTRACT

ABSTRACT

The World Health Organization (WHO) declared the COVID-19 epidemic to be a global pandemic in March 2020. COVID-19 is an infection caused by SARS-CoV-2, a coronavirus that utilizes the angiotensin-2 converting enzyme to penetrate thyroid and pituitary cells, and may result in a "cytokine storm". Based on the pathophysiological involvement of the pituitary-thyroid axis, the current review discusses the diagnosis of abnormal thyroid function test, and the management of patients presenting with thyrotoxicosis, thyroid-associated orbitopathy and hypothyroidism in the context of SARS-CoV-2 infection.

Subject(s)

Betacoronavirus; Coronavirus Infections/complications; Pandemics; Pneumonia, Viral/complications; Thyroid Diseases/etiology; Angiotensin-Converting Enzyme 2; Apoptosis; COVID-19; Coronavirus Infections/drug therapy; Coronavirus Infections/physiopathology; Cytokine Release Syndrome/etiology; Cytokine Release Syndrome/physiopathology; Disease Susceptibility; Graves Ophthalmopathy/complications; Humans; Hydroxychloroquine/adverse effects; Hydroxychloroquine/therapeutic use; Hypothyroidism/blood; Hypothyroidism/etiology; Hypothyroidism/physiopathology; Interleukin-6/physiology; Peptidyl-Dipeptidase A/analysis; Pituitary Gland/physiopathology; Pneumonia, Viral/drug therapy; Pneumonia, Viral/physiopathology; Receptors, Virus/analysis; SARS-CoV-2; Thyroid Diseases/blood; Thyroid Diseases/physiopathology; Thyroid Gland/chemistry; Thyroid Gland/pathology; Thyroid Gland/physiopathology; Thyroid Hormones/blood; Thyrotoxicosis/blood; Thyrotoxicosis/etiology; Thyrotoxicosis/physiopathology; Thyrotropin/blood; COVID-19 Drug Treatment

Keywords

COVID-19; Free T3; Free T4; Hypothyroidism; Hypothyroïdie; Orbitopathie; Orbitopathy; SARS-CoV-2; T3l; T4l; TSH; Thyrotoxicose; Thyrotoxicosis

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thyroid Diseases / Coronavirus Infections / Pandemics / Betacoronavirus Topics: Long Covid Language: English Journal: Ann Endocrinol (Paris) Year: 2020 Document Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google