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Syncope at SARS-CoV-2 onset.
Canetta, Ciro; Accordino, Silvia; Buscarini, Elisabetta; Benelli, Gianpaolo; La Piana, Giuseppe; Scartabellati, Alessandro; Viganò, Giovanni; Assandri, Roberto; Astengo, Alberto; Benzoni, Chiara; Gaudiano, Gianfranco; Cazzato, Daniele; Rossi, Davide Sebastiano; Usai, Susanna; Tramacere, Irene; Lauria, Giuseppe.
  • Canetta C; Emergency Medicine Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Accordino S; Emergency Medicine Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Buscarini E; Gastroenterology Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Benelli G; Radiology Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • La Piana G; Pneumology 2 Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Scartabellati A; Pneumology 1 Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Viganò G; Emergency Unit, Ospedale Maggiore di Crema, Crema, Italy.
  • Assandri R; Clinical Investigation Laboratory, Ospedale Maggiore di Crema, Crema, Italy.
  • Astengo A; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy; Department of Clinical Neurosciences, Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Benzoni C; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy; Department of Clinical Neurosciences, Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Gaudiano G; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy; Department of Clinical Neurosciences, Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Cazzato D; Department of Diagnostics and Technology, Clinical Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Rossi DS; Department of Diagnostics and Technology, Clinical Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Usai S; Department of Clinical Neurosciences, Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Tramacere I; Scientific Directorate, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
  • Lauria G; Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy; Department of Clinical Neurosciences, Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy. Electronic address: giuseppe.lauriapinter@istituto-besta.it.
Auton Neurosci ; 229: 102734, 2020 12.
Article in English | MEDLINE | ID: covidwho-778433
Semantic information from SemMedBD (by NLM)
1. Syncope PROCESS_OF Patients
Subject
Syncope
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PROCESS_OF
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Patients
2. Syncope PROCESS_OF Patients
Subject
Syncope
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
We describe clinical and laboratory findings in 35 patients tested positive for SARS-CoV-2 by reverse transcriptase-polymerase chain reaction on nasopharyngeal swab experiencing one or multiple syncope at disease onset. Clinical neurologic and cardiologic examination, and electrocardiographic findings were normal. Chest computed tomography showed findings consistent with interstitial pneumonia. Arterial blood gas analysis showed low pO2, pCO2, and ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) indicating hypocapnic hypoxemia. Patients who presented with syncope showed significantly lower heart rate as compared to 68 SARS-CoV-2 positive that did not. Such poorer than expected compensatory heart rate increase may have led to syncope based on individual susceptibility. We speculate that SARS-CoV-2 could have caused angiotensin-converting enzyme-2 (ACE2) receptor internalization in the nucleus of the solitary tract and other midbrain nuclei, impairing baroreflex and chemoreceptor response, and inhibiting the compensatory tachycardia during acute hypocapnic hypoxemia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Syncope / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Auton Neurosci Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: J.autneu.2020.102734

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Syncope / COVID-19 Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Auton Neurosci Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: J.autneu.2020.102734