Current pharmacological intervention and development of targeting IVIG resistance in Kawasaki disease.
Curr Opin Pharmacol
; 54: 72-81, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-778682
ABSTRACT
Kawasaki disease is an acute childhood self-limited vasculitis, causing the swelling or inflammation of medium-sized arteries, eventually leading to cardiovascular problems such as coronary artery aneurysms. Acetylsalicylic acid combined with intravenous immunoglobulin (IVIG) is the standard treatment of Kawasaki disease (KD). However, a rising number of IVIG resistant cases were reported with severe disease complications such as the KD Shock Syndrome or KD-Macrophage activation syndrome. Recent reports have depicted the overlapped number of children with SARS-CoV-2 and KD, which was called multisystem inflammatory syndrome. Simultaneously, the incidence rate of KD-like diseases are increased after the outbreak of COVID-19, suggesting the virus may be associated with KD. New intervention is important to overcome the problem of IVIG treatment resistance. This review aims to introduce the current pharmacological intervention and possible resistance genes for the discovery of new drug for IVIG resistant KD.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drug Resistance
/
Immunoglobulins, Intravenous
/
Mucocutaneous Lymph Node Syndrome
Type of study:
Experimental Studies
/
Observational study
Limits:
Humans
Language:
English
Journal:
Curr Opin Pharmacol
Journal subject:
Pharmacology
Year:
2020
Document Type:
Article
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