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Current pharmacological intervention and development of targeting IVIG resistance in Kawasaki disease.
Zhang, Rui Long; Lo, Hang Hong; Lei, Cheng; Ip, Nikki; Chen, Juan; Law, Betty Yuen-Kwan.
  • Zhang RL; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, SAR China.
  • Lo HH; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, SAR China.
  • Lei C; Department of Pediatrics, Kiang Wu Hospital, Macao, SAR China.
  • Ip N; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, SAR China.
  • Chen J; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Electronic address: chenjuan2014@cqmu.edu.
  • Law BY; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, SAR China. Electronic address: yklaw@must.edu.mo.
Curr Opin Pharmacol ; 54: 72-81, 2020 10.
Article in English | MEDLINE | ID: covidwho-778682
Semantic information from SemMedBD (by NLM)
1. immunoglobulin ASSOCIATED_WITH C0026691
Subject
immunoglobulin
Predicate
ASSOCIATED_WITH
Object
C0026691
2. Vasculitis CAUSES Arteritis
Subject
Vasculitis
Predicate
CAUSES
Object
Arteritis
3. Vasculitis CAUSES Edema
Subject
Vasculitis
Predicate
CAUSES
Object
Edema
4. Mucocutaneous Lymph Node Syndrome CAUSES cardiovascular problem
Subject
Mucocutaneous Lymph Node Syndrome
Predicate
CAUSES
Object
cardiovascular problem
5. aspirin COEXISTS_WITH immunoglobulin
Subject
aspirin
Predicate
COEXISTS_WITH
Object
immunoglobulin
6. 2019 novel coronavirus PROCESS_OF Child
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Child
7. Mucocutaneous Lymph Node Syndrome COEXISTS_WITH Virus
Subject
Mucocutaneous Lymph Node Syndrome
Predicate
COEXISTS_WITH
Object
Virus
8. New medications TREATS Mucocutaneous Lymph Node Syndrome
Subject
New medications
Predicate
TREATS
Object
Mucocutaneous Lymph Node Syndrome
9. immunoglobulins, intravenous ASSOCIATED_WITH Mucocutaneous Lymph Node Syndrome
Subject
immunoglobulins, intravenous
Predicate
ASSOCIATED_WITH
Object
Mucocutaneous Lymph Node Syndrome
10. Vasculitis CAUSES Arteritis
Subject
Vasculitis
Predicate
CAUSES
Object
Arteritis
11. Vasculitis CAUSES Edema
Subject
Vasculitis
Predicate
CAUSES
Object
Edema
12. Mucocutaneous Lymph Node Syndrome CAUSES cardiovascular problem
Subject
Mucocutaneous Lymph Node Syndrome
Predicate
CAUSES
Object
cardiovascular problem
13. aspirin COEXISTS_WITH immunoglobulins, intravenous
Subject
aspirin
Predicate
COEXISTS_WITH
Object
immunoglobulins, intravenous
14. 2019 novel coronavirus PROCESS_OF Child
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Child
15. Mucocutaneous Lymph Node Syndrome COEXISTS_WITH Virus
Subject
Mucocutaneous Lymph Node Syndrome
Predicate
COEXISTS_WITH
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Virus
16. New medications TREATS Mucocutaneous Lymph Node Syndrome
Subject
New medications
Predicate
TREATS
Object
Mucocutaneous Lymph Node Syndrome
ABSTRACT
Kawasaki disease is an acute childhood self-limited vasculitis, causing the swelling or inflammation of medium-sized arteries, eventually leading to cardiovascular problems such as coronary artery aneurysms. Acetylsalicylic acid combined with intravenous immunoglobulin (IVIG) is the standard treatment of Kawasaki disease (KD). However, a rising number of IVIG resistant cases were reported with severe disease complications such as the KD Shock Syndrome or KD-Macrophage activation syndrome. Recent reports have depicted the overlapped number of children with SARS-CoV-2 and KD, which was called multisystem inflammatory syndrome. Simultaneously, the incidence rate of KD-like diseases are increased after the outbreak of COVID-19, suggesting the virus may be associated with KD. New intervention is important to overcome the problem of IVIG treatment resistance. This review aims to introduce the current pharmacological intervention and possible resistance genes for the discovery of new drug for IVIG resistant KD.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Resistance / Immunoglobulins, Intravenous / Mucocutaneous Lymph Node Syndrome Limits: Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Resistance / Immunoglobulins, Intravenous / Mucocutaneous Lymph Node Syndrome Limits: Humans Language: English Journal: Curr Opin Pharmacol Journal subject: Pharmacology Year: 2020 Document Type: Article