Clinical features of patients with type 2 diabetes with and without Covid-19: A case control study (CoViDiab I).
Diabetes Res Clin Pract
; 169: 108454, 2020 Nov.
Article
in English
| MEDLINE | ID: covidwho-778739
ABSTRACT
AIMS:
To evaluate whether subjects with diabetes hospitalized for Coronavirus disease-19 (Covid-19) represent a subgroup of patients with high-risk clinical features compared to patients with diabetes without Covid-19.METHODS:
In this case-control study 79 patients with type 2 diabetes out of 354 adults hospitalized for Covid-19 and 158 controls with type 2 diabetes but without Covid-19, matched for age and gender, were enrolled. Medical history and concomitant therapies were retrieved from medical charts and compared between cases and controls, controlling for confounders.RESULTS:
Fully-adjusted multivariate logistic regression model showed that previous CVD history did not differ between patients with and without Covid-19 (odds ratio 1.40, 95% confidence interval [CI] 0.59-3.32, p = 0.45). A higher prevalence of chronic obstructive pulmonary disease (COPD) (OR 3.72, 95%CI 1.42-9.72, p = 0.007) and of chronic kidney disease (CKD) (OR 3.08, 95%CI 1.18-8.06, p = 0.022) and a lower prevalence of ever smokers (OR 0.30, 95%CI 0.13-0.67, p = 0.003), of users of lipid lowering agents (OR 0.26, 95%CI 0.12-0.54, p < 0.001), and of anti-hypertensive drugs (OR 0.39, 95%CI 0.16-0.93, p = 0.033) were found among cases.CONCLUSIONS:
CVD prevalence does not differ between people with diabetes with and without Covid-19 requiring hospitalization. An increased prevalence of COPD and of CKD in Covid-19 patients with type 2 diabetes is suggested. These findings aid to clarify the relationship between underlying conditions and SARS-CoV-2 infection in the high-risk group of patients with diabetes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pulmonary Disease, Chronic Obstructive
/
Diabetes Mellitus, Type 2
/
Renal Insufficiency, Chronic
/
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Diabetes Res Clin Pract
Journal subject:
Endocrinology
Year:
2020
Document Type:
Article
Affiliation country:
J.diabres.2020.108454
Similar
MEDLINE
...
LILACS
LIS