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Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients.
Burgos-Blasco, Barbara; Güemes-Villahoz, Noemi; Santiago, Jose Luis; Fernandez-Vigo, Jose Ignacio; Espino-Paisán, Laura; Sarriá, Beatriz; García-Feijoo, Julian; Martinez-de-la-Casa, Jose Maria.
  • Burgos-Blasco B; Ophthalmology Department, Hospital Clínico San Carlos. Madrid, Spain. Electronic address: bburgos171@hotmail.com.
  • Güemes-Villahoz N; Ophthalmology Department, Hospital Clínico San Carlos. Madrid, Spain.
  • Santiago JL; Immunology Department. Hospital Fundación Jimenez Diaz. Madrid, Spain.
  • Fernandez-Vigo JI; Ophthalmology Department, Hospital Clínico San Carlos. Madrid, Spain.
  • Espino-Paisán L; Laboratorio de investigación en genética de enfermedades complejas, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC). Madrid, Spain.
  • Sarriá B; Department of Metabolism and Nutrition. Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC). Madrid, Spain.
  • García-Feijoo J; Ophthalmology Department. Instituto de investigación sanitaria del Hospital Clínico San Carlos (IdISSC). IIORC. Universidad Complutense. Madrid, Spain.
  • Martinez-de-la-Casa JM; Ophthalmology Department. Instituto de investigación sanitaria del Hospital Clínico San Carlos (IdISSC). IIORC. Universidad Complutense. Madrid, Spain.
Exp Eye Res ; 200: 108253, 2020 11.
Article in English | MEDLINE | ID: covidwho-778845
ABSTRACT
The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF).In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tears / Cytokines / Coronavirus Infections / Eye Proteins / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Exp Eye Res Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tears / Cytokines / Coronavirus Infections / Eye Proteins / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Exp Eye Res Year: 2020 Document Type: Article