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Rapid screening of COVID-19 patients using white blood cell scattergrams, a study on 381 patients.
Osman, Jennifer; Lambert, Jérome; Templé, Marie; Devaux, Floriane; Favre, Rémy; Flaujac, Claire; Bridoux, Delphine; Marque-Juillet, Stéphanie; Bruneel, Fabrice; Mignon, François; Diaz-Flores, Ernesto; Hentgen, Véronique; Greder-Belan, Alix; Azarian, Reza; Koukabi, Mehrsa; Rousselot, Philippe; Raggueneau, Victoria; Manéglier, Benjamin.
  • Osman J; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Lambert J; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Templé M; INSERM UMR1153 ECSTRRA Team, Paris, France.
  • Devaux F; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Favre R; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Flaujac C; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Bridoux D; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Marque-Juillet S; Department of Hematobiology, CH Versailles, Le Chesnay, France.
  • Bruneel F; Department of Virology, CH de Versailles, Le Chesnay, France.
  • Mignon F; Department of Critical Care, CH de Versailles, Le Chesnay, France.
  • Diaz-Flores E; Department of Radiology, CH de Versailles, Le Chesnay, France.
  • Hentgen V; Department of Pediatrics, Benioff Children's Hospital, Helen Diller Comprehensive cancer center, UCSF, San Francisco, CA, USA.
  • Greder-Belan A; Department of Pediatrics, CH de Versailles, Le Chesnay, France.
  • Azarian R; Department of Internal Medecine and Infectious Diseases, CH de Versailles, Le Chesnay, France.
  • Koukabi M; Department of Pneumology, CH de Versailles, Le Chesnay, France.
  • Rousselot P; Emergency department, CH de Versailles, Le Chesnay, France.
  • Raggueneau V; Department of Hematology and Oncology, CH de Versailles, Le Chesnay, France.
  • Manéglier B; UMR1184, University of Versailles Saint-Quentin-en-Yvelines and Paris Saclay, Versailles, France.
Br J Haematol ; 190(5): 718-722, 2020 09.
Article in English | MEDLINE | ID: covidwho-780755
ABSTRACT
Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific 'sandglass' aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the 'sandglass' aspect were 85·9% and 83·5% respectively. The positive predictive value was 94·3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Mass Screening / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2020 Document Type: Article Affiliation country: Bjh.16943

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Mass Screening / Coronavirus Infections / Betacoronavirus Type of study: Diagnostic study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Br J Haematol Year: 2020 Document Type: Article Affiliation country: Bjh.16943