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The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series.
Goss, Matthew B; Galván, N Thao N; Ruan, Wenly; Munoz, Flor M; Brewer, Eileen D; O'Mahony, Christine A; Melicoff-Portillo, Ernestina; Dreyer, William J; Miloh, Tamir A; Cigarroa, Francisco G; Ranch, Daniel; Yoeli, Dor; Adams, Megan A; Koohmaraie, Sarah; Harter, Diana M; Rana, Abbas; Cotton, Ronald T; Carter, Beth; Patel, Shreena; Moreno, Nicolas F; Leung, Daniel H; Goss, John A.
  • Goss MB; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Galván NTN; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
  • Ruan W; Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition Section, Baylor College of Medicine, Houston, TX, USA.
  • Munoz FM; Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, TX, USA.
  • Brewer ED; Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • O'Mahony CA; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
  • Melicoff-Portillo E; Pulmonary Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Dreyer WJ; Cardiology Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Miloh TA; Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Cigarroa FG; Division of Abdominal Transplantation, University Transplant Center, UT Health San Antonio, San Antonio, TX, USA.
  • Ranch D; Division of Nephrology, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA.
  • Yoeli D; Division of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, USA.
  • Adams MA; Division of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, USA.
  • Koohmaraie S; Liver Transplantation Service, Texas Children's Hospital, Houston, TX, USA.
  • Harter DM; Transplant Services, Texas Children's Hospital, Houston, TX, USA.
  • Rana A; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
  • Cotton RT; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
  • Carter B; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, USA.
  • Patel S; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, USA.
  • Moreno NF; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Leung DH; Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition Section, Baylor College of Medicine, Houston, TX, USA.
  • Goss JA; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Pediatr Transplant ; 25(3): e13868, 2021 05.
Article in English | MEDLINE | ID: covidwho-781008
ABSTRACT
The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult transplant recipients have been published, literature centered on the pediatric population is limited. We herein report a multi-center, multi-organ cohort analysis of COVID-19-positive transplant recipients ≤ 18 years at time of transplant. Data were collected via institutions' respective electronic medical record systems. Local review boards approved this cross-institutional study. Among 5 transplant centers, 26 patients (62% male) were reviewed with a median age of 8 years. Six were heart recipients, 8 kidney, 10 liver, and 2 lung. Presenting symptoms included cough (n = 12 (46%)), fever (n = 9 (35%)), dry/sore throat (n = 3 (12%)), rhinorrhea (n = 3 (12%)), anosmia (n = 2 (8%)), chest pain (n = 2 (8%)), diarrhea (n = 2 (8%)), dyspnea (n = 1 (4%)), and headache (n = 1 (4%)). Six patients (23%) were asymptomatic. No patient required supplemental oxygen, intubation, or ECMO. Eight patients (31%) were hospitalized at time of diagnosis, 3 of whom were already admitted for unrelated problems. Post-transplant immunosuppression was reduced for only 2 patients (8%). All symptomatic patients recovered within 7 days. Our multi-institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID-19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Immunocompromised Host / Perioperative Care / COVID-19 / Graft Rejection / Immunosuppressive Agents Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Pediatr Transplant Journal subject: Pediatrics / Transplantation Year: 2021 Document Type: Article Affiliation country: Petr.13868

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Immunocompromised Host / Perioperative Care / COVID-19 / Graft Rejection / Immunosuppressive Agents Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Pediatr Transplant Journal subject: Pediatrics / Transplantation Year: 2021 Document Type: Article Affiliation country: Petr.13868