Successfully treated severe COVID-19 and invasive aspergillosis in early hematopoietic cell transplantation setting.

Spadea, Manuela; Carraro, Francesca; Saglio, Francesco; Vassallo, Elena; Pessolano, Rosanna; Berger, Massimo; Scolfaro, Carlo; Grassitelli, Sergio; Fagioli, Franca

Spadea, Manuela; Carraro, Francesca; Saglio, Francesco; Vassallo, Elena; Pessolano, Rosanna; Berger, Massimo; Scolfaro, Carlo; Grassitelli, Sergio; Fagioli, Franca.

Spadea M; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Carraro F; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Saglio F; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Vassallo E; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Pessolano R; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Berger M; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Scolfaro C; Pediatric Infectious Disease Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Grassitelli S; Pediatric Intensive Care Unit, Regina Margherita Children's Hospital, Turin, Italy.
Fagioli F; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.

Transpl Infect Dis ; 23(2): e13470, 2021 04.

Article in English | MEDLINE | ID: covidwho-781039

Subject(s)

COVID-19 Drug Treatment; Coinfection/drug therapy; Hematopoietic Stem Cell Transplantation/adverse effects; Immunosuppressive Agents/adverse effects; Invasive Pulmonary Aspergillosis/drug therapy; Adenosine Monophosphate/administration & dosage; Adenosine Monophosphate/analogs & derivatives; Alanine/administration & dosage; Alanine/analogs & derivatives; Amphotericin B/administration & dosage; COVID-19/diagnosis; COVID-19/immunology; COVID-19/virology; Coinfection/diagnosis; Coinfection/immunology; Coinfection/microbiology; Drug Therapy, Combination/methods; Graft vs Host Disease/immunology; Graft vs Host Disease/prevention & control; Humans; Immunosuppressive Agents/administration & dosage; Invasive Pulmonary Aspergillosis/diagnosis; Invasive Pulmonary Aspergillosis/immunology; Invasive Pulmonary Aspergillosis/microbiology; Lung/diagnostic imaging; Male; Methylprednisolone/administration & dosage; Myeloablative Agonists/administration & dosage; Myeloablative Agonists/adverse effects; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy; Pyrazoles/administration & dosage; Pyrimidines; SARS-CoV-2/immunology; SARS-CoV-2/isolation & purification; Severity of Illness Index; Tomography, X-Ray Computed; Transplantation Conditioning/adverse effects; Transplantation Conditioning/methods; Treatment Outcome; Young Adult

Keywords

COVID-19 management; hematopoietic cell transplantation; immune suppressed patients; invasive aspergillosis co-infection; ruxolitinib; severe COVID-19

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hematopoietic Stem Cell Transplantation / Invasive Pulmonary Aspergillosis / Coinfection / COVID-19 Drug Treatment / Immunosuppressive Agents Type of study: Case report / Diagnostic study / Prognostic study Language: English Journal: Transpl Infect Dis Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Tid.13470

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