Severe acute respiratory syndrome-coronavirus-2: Current advances in therapeutic targets and drug development.
Rev Med Virol
; 31(3): e2174, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-784380
ABSTRACT
The current pandemic of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has quickly emerged as a global health concern with government bodies worldwide taking drastic control measures. Understanding the virology of SARS-CoV-2, its molecular mechanisms, and its pathogenesis are required for a targeted therapeutic approach. In this review, we highlight the current molecular and drug advances that target SARS-CoV-2 at the genome level. We also summarize studies that therapeutically target the host angiotensin-converting enzyme 2 and proteases. Finally, we summarize antibody-mediated therapeutic approaches, as well as recent trends in vaccine development. Hence, the purpose of this study is to investigate different molecular targets in SARS-CoV-2 pathogenesis and their usefulness in developing strategies for drug development.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Serine Endopeptidases
/
Spike Glycoprotein, Coronavirus
/
Angiotensin-Converting Enzyme 2
/
Coronavirus 3C Proteases
/
COVID-19 Drug Treatment
/
Antibodies, Monoclonal
Topics:
Vaccines
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Rev Med Virol
Journal subject:
Virology
Year:
2021
Document Type:
Article
Affiliation country:
Rmv.2174
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