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Hydrogen: A Novel Option in Human Disease Treatment.
Yang, Mengling; Dong, Yinmiao; He, Qingnan; Zhu, Ping; Zhuang, Quan; Shen, Jie; Zhang, Xueyan; Zhao, Mingyi.
  • Yang M; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
  • Dong Y; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
  • He Q; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
  • Zhu P; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, China.
  • Zhuang Q; Transplantation Center of the 3rd Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
  • Shen J; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
  • Zhang X; Xiangya School of Medicine, Central South University, Hunan Province, Changsha 410013, China.
  • Zhao M; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan Province, Changsha 410013, China.
Oxid Med Cell Longev ; 2020: 8384742, 2020.
Article in English | MEDLINE | ID: covidwho-788248
ABSTRACT
H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hydrogen Type of study: Prognostic study Limits: Humans Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: 2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hydrogen Type of study: Prognostic study Limits: Humans Language: English Journal: Oxid Med Cell Longev Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: 2020