Hydrogen: A Novel Option in Human Disease Treatment.
Oxid Med Cell Longev
; 2020: 8384742, 2020.
Article
in English
| MEDLINE | ID: covidwho-788248
ABSTRACT
H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hydrogen
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Oxid Med Cell Longev
Journal subject:
Metabolism
Year:
2020
Document Type:
Article
Affiliation country:
2020
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