Possible effect of epinephrine in minimizing COVID-19 severity: a review.
J Int Med Res
; 48(9): 300060520958594, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-788437
ABSTRACT
OBJECTIVE:
Coronavirus disease 2019 (COVID-19) shows a wide range of severity, ranging from an asymptomatic presentation to a severe illness requiring intensive care unit admission. Identification of a strategy to manage the severity of this disease will not only help to reduce its case fatality but also help to remove some of the burden from the already overwhelmed health care systems. While successful management of symptoms in general is important, identifying measures to modify the severity of the illness is a key factor in the fight against this pandemic.METHODS:
This paper presents a short literature review to suggest a new treatment modality for COVID-19.RESULTS:
COVID-19 is less severe and rarely fatal in children than in adults, which could be caused by greater fluctuations of plasma epinephrine in children. Our literature survey endorses this hypothesis according to both the epidemiological and immunological findings.CONCLUSION:
Application of epinephrine pulses with a specific amplitude may be considered an intervention to minimize the severity of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Epinephrine
/
Circadian Rhythm
/
Coronavirus Infections
/
CD8-Positive T-Lymphocytes
/
Pandemics
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
J Int Med Res
Year:
2020
Document Type:
Article
Affiliation country:
0300060520958594
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