Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.

Gupta, Satya P

Gupta, Satya P.

Gupta SP; Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut-250005, India.

Curr Top Med Chem ; 20(26): 2362-2378, 2020.

Article in English | MEDLINE | ID: covidwho-789061

ABSTRACT

ABSTRACT

The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a Receptor-binding Domain (RBD) that mediates the binding to host cell receptor, Angiotensin Converting Enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of Convalescent Plasma (CP) therapy to treat COVID-19 is also discussed.

Subject(s)

Antiviral Agents/therapeutic use; Coronavirus Infections/epidemiology; Coronavirus Infections/therapy; Pandemics; Peptidyl-Dipeptidase A/chemistry; Pneumonia, Viral/epidemiology; Pneumonia, Viral/therapy; Spike Glycoprotein, Coronavirus/genetics; Adenosine Monophosphate/analogs & derivatives; Adenosine Monophosphate/therapeutic use; Alanine/analogs & derivatives; Alanine/therapeutic use; Angiotensin-Converting Enzyme 2; Betacoronavirus/drug effects; Betacoronavirus/immunology; Betacoronavirus/pathogenicity; Betacoronavirus/ultrastructure; COVID-19; COVID-19 Vaccines; Coronavirus Infections/diagnosis; Coronavirus Infections/immunology; Coronavirus Infections/prevention & control; Gene Expression; Host-Pathogen Interactions/drug effects; Host-Pathogen Interactions/genetics; Host-Pathogen Interactions/immunology; Humans; Hydroxychloroquine/therapeutic use; Immunization, Passive/methods; Ivermectin/therapeutic use; Models, Molecular; Niclosamide/therapeutic use; Peptidyl-Dipeptidase A/genetics; Peptidyl-Dipeptidase A/immunology; Pneumonia, Viral/diagnosis; Pneumonia, Viral/immunology; Protein Interaction Domains and Motifs/drug effects; Protein Structure, Secondary; Severe acute respiratory syndrome-related coronavirus/drug effects; Severe acute respiratory syndrome-related coronavirus/immunology; Severe acute respiratory syndrome-related coronavirus/pathogenicity; Severe acute respiratory syndrome-related coronavirus/ultrastructure; SARS-CoV-2; Severe Acute Respiratory Syndrome; Spike Glycoprotein, Coronavirus/antagonists & inhibitors; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/immunology; Viral Vaccines/biosynthesis; COVID-19 Serotherapy

Keywords

2019-CoV-2; Anti-COVID-19 drugs; Antibodies; COVID-19; Convalescent plasma (CP) therapy; Epitopes; Vaccines

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Spike Glycoprotein, Coronavirus Type of study: Diagnostic study / Observational study Topics: Vaccines Language: English Journal: Curr Top Med Chem Journal subject: Chemistry Year: 2020 Document Type: Article Affiliation country: 1568026620666200922112300

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