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RNAemia Corresponds to Disease Severity and Antibody Response in Hospitalized COVID-19 Patients.
Eberhardt, Kirsten Alexandra; Meyer-Schwickerath, Charlotte; Heger, Eva; Knops, Elena; Lehmann, Clara; Rybniker, Jan; Schommers, Philipp; Eichenauer, Dennis A; Kurth, Florian; Ramharter, Michael; Kaiser, Rolf; Holtick, Udo; Klein, Florian; Jung, Norma; Di Cristanziano, Veronica.
  • Eberhardt KA; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
  • Meyer-Schwickerath C; Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Heger E; Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, Germany.
  • Knops E; Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50935 Cologne, Germany.
  • Lehmann C; Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Rybniker J; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50937 Cologne, Germany.
  • Schommers P; Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany.
  • Eichenauer DA; Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Kurth F; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50937 Cologne, Germany.
  • Ramharter M; Center for Molecular Medicine Cologne, University of Cologne, 50937 Cologne, Germany.
  • Kaiser R; Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Holtick U; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50937 Cologne, Germany.
  • Klein F; Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
  • Jung N; Center of Integrated Oncology ABCD, University Hospital of Cologne, 50937 Cologne, Germany.
  • Di Cristanziano V; Intensive Care Program, Department I of Internal Medicine, University Hospital of Cologne, 50937 Cologne, Germany.
Viruses ; 12(9)2020 09 18.
Article in English | MEDLINE | ID: covidwho-789516
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global health emergency. To improve the understanding of the systemic component of SARS-CoV-2, we investigated if viral load dynamics in plasma and respiratory samples are associated with antibody response and severity of coronavirus disease 2019 (COVID-19). SARS-CoV-2 RNA was found in plasma samples from 14 (44%) out of 32 patients. RNAemia was detected in 5 out of 6 fatal cases. Peak IgG values were significantly lower in mild/moderate than in severe (0.6 (interquartile range, IQR, 0.4-3.2) vs. 11.8 (IQR, 9.9-13.0), adjusted p = 0.003) or critical cases (11.29 (IQR, 8.3-12.0), adjusted p = 0.042). IgG titers were significantly associated with virus Ct (Cycle threshold) value in plasma and respiratory specimens ((ß = 0.4, 95% CI (confidence interval, 0.2; 0.5), p < 0.001 and ß = 0.5, 95% CI (0.2; 0.6), p = 0.002). A classification as severe or a critical case was additionally inversely associated with Ct values in plasma in comparison to mild/moderate cases (ß = -3.3, 95% CI (-5.8; 0.8), p = 0.024 and ß = -4.4, 95% CI (-7.2; 1.6), p = 0.007, respectively). Based on the present data, our hypothesis is that the early stage of SARS-CoV-2 infection is characterized by a primary RNAemia, as a potential manifestation of a systemic infection. Additionally, the viral load in plasma seems to be associated with a worse disease outcome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: V12091045

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: V12091045