Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2-Induced Cytokine Storm.
J Immunol
; 205(10): 2566-2575, 2020 11 15.
Article
in English
| MEDLINE | ID: covidwho-789578
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which rapidly became a pandemic of global proportions. Sepsis is commonly present with high lethality in the severe forms of the disease. The virus-induced cytokine storm puts the immune system in overdrive at the expense of the pathogen-specific immune response and is likely to underlie the most advanced COVID-19 clinical features, including sepsis-related multiple organ dysfunction as well as the pathophysiological changes found in the lungs. We review the major therapeutic strategies that have been considered for sepsis and might be amenable to repurposing for COVID-19. We also discuss two different immunization strategies that have the potential to confer antiviral heterologous protection innate-induced trained immunity and adaptive-induced immune response resetting.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Cytokines
/
Coronavirus Infections
/
Adaptive Immunity
/
Pandemics
/
Betacoronavirus
/
Immunity, Innate
/
Multiple Organ Failure
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Immunol
Year:
2020
Document Type:
Article
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