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A novel risk score to predict cardiovascular complications in patients with coronavirus disease 2019 (COVID-19): A retrospective, multicenter, observational study.
Huang, Dong; Yang, Huan; Yu, He; Wang, Ting; Yao, Rong; Liang, Zongan.
  • Huang D; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yang H; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yu H; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Wang T; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Yao R; Emergency Medical Laboratory, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Liang Z; Disaster Medical Center, Sichuan University, Chengdu, Sichuan, China.
Immun Inflamm Dis ; 8(4): 638-649, 2020 12.
Article in English | MEDLINE | ID: covidwho-792326
ABSTRACT

BACKGROUND:

We conducted this study to explore a novel risk score to predict cardiovascular complications in patients with coronavirus disease 2019 (COVID-19).

METHODS:

The current study was a retrospective, multicenter, observational study. The clinical data of COVID-19 patients at admission were collected. Patients were randomly divided into training set and testing set (70% vs. 30% of patients). Independent risk factors were identified via logistic regression analysis.

RESULTS:

Finally, 1207 patients were included. Ten independent risk factors associated with cardiovascular complications were identified in training set male (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.18, 2.85), age ≥ 60 years old (OR 2.01; 95% CI 1.3, 3.2), cough (OR 1.86; 95% CI 1.16, 3), chronic heart disease (OR 2.3; 95% CI 1.19, 4.46), lymphocyte count ≤1.1 × 109 /L at admission (OR 1.60; 95% CI 1.03, 2.47), blood urea nitrogen ≥7 mmol/L at admission (OR 2.14; 95% CI 1.27, 3.62), estimated glomerular filtration rate ≤90 ml/min/1.73 m2 at admission (OR 2.08; 95% CI 1.13, 3.83), activated partial thromboplastin time ≥37 s (OR 3.07; 95% CI 1.37, 6.86), D-dimer ≥ 0.5 mg/L (OR 2.12; 95% CI 1.33, 3.36) and procalcitonin ≥0.5 µg/L (OR 3.58; 95% CI 1.40, 9.14). The area under curve of ROC curve was 0.773 (95% CI 0.723, 0.822; p < .01). The risk score had robustness and generalizability after validation. Cardiovascular complications were significantly associated with poorer survivals (log-rank test p < .001).

CONCLUSIONS:

We developed and validated a novel risk score, which has a promising predictive capacity for cardiovascular complications in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Immun Inflamm Dis Year: 2020 Document Type: Article Affiliation country: Iid3.353

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Immun Inflamm Dis Year: 2020 Document Type: Article Affiliation country: Iid3.353