Factors related to asymptomatic or severe COVID-19 infection.

Mayoral, Eduardo Pérez-Campos; Hernández-Huerta, María Teresa; Pérez-Campos Mayoral, Laura; Matias-Cervantes, Carlos Alberto; Mayoral-Andrade, Gabriel; Barrios, Luis Ángel Laguna; Pérez-Campos, Eduardo

Mayoral, Eduardo Pérez-Campos; Hernández-Huerta, María Teresa; Pérez-Campos Mayoral, Laura; Matias-Cervantes, Carlos Alberto; Mayoral-Andrade, Gabriel; Barrios, Luis Ángel Laguna; Pérez-Campos, Eduardo.

Mayoral EP; Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico.
Hernández-Huerta MT; CONACyT, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico.
Pérez-Campos Mayoral L; Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico. Electronic address: laurapcm@prodigy.net.mx.
Matias-Cervantes CA; CONACyT, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico.
Mayoral-Andrade G; Centro de Investigación Facultad de Medicina UNAM-UABJO, Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico.
Barrios LÁL; Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico.
Pérez-Campos E; Facultad de Medicina y Cirugía, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca 68020, Mexico; Tecnológico Nacional de México/IT Oaxaca, Oaxaca 68020, Mexico; Laboratorio de Patología Clinica "Eduardo Pérez Ortega", Oaxaca 68000, Mexico. Electronic address: perezcampos@prodigy.net.mx.

Med Hypotheses ; 144: 110296, 2020 Nov.

Article in English | MEDLINE | ID: covidwho-792856

ABSTRACT

ABSTRACT

The factors that may contribute to a COVID-19 patient remaining in the asymptomatic stage, or to the infection evolving into the more serious stages are examined. In particular, we refer to the TMPRSS2 expression profile, balance of androgen and estrogen, blood group-A and/or B, nonsynonymous mutations in ORF3, and proteins NS7b and NS8 in SARS-CoV-2. Also, we review other factors related to the susceptibility and pathogenicity of SARS-CoV-2.

Subject(s)

Asymptomatic Infections; COVID-19/genetics; Genetic Predisposition to Disease; SARS-CoV-2; Serine Endopeptidases/genetics; Alleles; Androgens/metabolism; Angiotensin-Converting Enzyme 2/genetics; COVID-19/virology; Coronavirus RNA-Dependent RNA Polymerase; Exome; Female; Gene Expression Profiling; Histocompatibility Antigens Class I/genetics; Humans; Male; Models, Theoretical; Mutation; Open Reading Frames; Polymorphism, Single Nucleotide; Viral Nonstructural Proteins/genetics; Vitamin D/analogs & derivatives; Vitamin D/metabolism

Keywords

25-Hydroxyvitamin D (25(OH)D); ACE2; Androgen; Asymptomatic; Blood group; COVID-19 infection; Factors; Histocompatibility complex (MHC) class I; Mutation

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Genetic Predisposition to Disease / Asymptomatic Infections / SARS-CoV-2 / COVID-19 Limits: Female / Humans / Male Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.110296

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