COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment.
J Neuroimmunol
; 349: 577400, 2020 12 15.
Article
in English
| MEDLINE | ID: covidwho-792960
ABSTRACT
Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain MRI and CSF analysis were unremarkable, while EEG showed slowing with frontal sharp waves. Neuropsychiatric symptoms resolved following treatment with tocilizumab. CNS involvement in COVID-19 may present as a subacute encephalopathy characterized by prominent frontal lobe dysfunction, with language disturbances as first neurological manifestation. Future studies should further investigate the role of tocilizumab in treating COVID-19-related encephalopathy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aphasia
/
Brain Diseases
/
Antibodies, Monoclonal, Humanized
/
Cytokine Release Syndrome
/
COVID-19
Type of study:
Case report
Topics:
Long Covid
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Journal:
J Neuroimmunol
Year:
2020
Document Type:
Article
Affiliation country:
J.jneuroim.2020.577400
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