Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk.

Nelson, Christopher P; Sama, Iziah E; Codd, Veryan; Webb, Thomas R; Ye, Shu; Lang, Chim C; Voors, Adriaan A; Ng, Leong L; Samani, Nilesh J

Nelson, Christopher P; Sama, Iziah E; Codd, Veryan; Webb, Thomas R; Ye, Shu; Lang, Chim C; Voors, Adriaan A; Ng, Leong L; Samani, Nilesh J.

Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Sama IE; Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (I.E.S., A.A.V.).
Codd V; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Webb TR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Ye S; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Lang CC; Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee Ninewells Hospital and Medical School, United Kingdom (C.C..).
Voors AA; Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands (I.E.S., A.A.V.).
Ng LL; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).
Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (C.P.N., V.C., T.R.W., S.Y., L.L.N., N.J.S.).

Circulation ; 142(11): 1117-1119, 2020 09 15.

Article in English | MEDLINE | ID: covidwho-795524

Subject(s)

Betacoronavirus; Chromosomes, Human, Pair 12/genetics; Chromosomes, Human, Pair 21/genetics; Chromosomes, Human, X/genetics; Coronavirus Infections/genetics; Gene Expression Regulation, Enzymologic/genetics; Peptidyl-Dipeptidase A/blood; Pneumonia, Viral/genetics; Polymorphism, Single Nucleotide; Receptors, Virus/blood; Sex Characteristics; Aged; Aged, 80 and over; Alleles; Angiotensin-Converting Enzyme 2; COVID-19; Coronavirus Infections/blood; Coronavirus Infections/enzymology; Coronavirus Infections/epidemiology; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Hepatocyte Nuclear Factor 1-alpha/genetics; Humans; INDEL Mutation; Linkage Disequilibrium; Male; Middle Aged; Pandemics; Peptidyl-Dipeptidase A/biosynthesis; Peptidyl-Dipeptidase A/genetics; Pneumonia, Viral/blood; Pneumonia, Viral/enzymology; Pneumonia, Viral/epidemiology; Receptors, Virus/biosynthesis; Receptors, Virus/genetics; Risk; SARS-CoV-2; Sex Distribution; Transcriptional Regulator ERG/genetics

Keywords

COVID-19; angiotensin converting enzyme 2; genome-wide association study; severe acute respiratory syndrome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Receptors, Virus / Chromosomes, Human, Pair 12 / Chromosomes, Human, Pair 21 / Gene Expression Regulation, Enzymologic / Sex Characteristics / Coronavirus Infections / Peptidyl-Dipeptidase A / Polymorphism, Single Nucleotide / Chromosomes, Human, X Type of study: Observational study / Prognostic study Language: English Journal: Circulation Year: 2020 Document Type: Article

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