Weak Induction of Interferon Expression by Severe Acute Respiratory Syndrome Coronavirus 2 Supports Clinical Trials of Interferon-&#955; to Treat Early Coronavirus Disease 2019.

O'Brien, Thomas R; Thomas, David L; Jackson, Sarah S; Prokunina-Olsson, Ludmila; Donnelly, Raymond P; Hartmann, Rune

Weak Induction of Interferon Expression by Severe Acute Respiratory Syndrome Coronavirus 2 Supports Clinical Trials of Interferon-λ to Treat Early Coronavirus Disease 2019.

O'Brien, Thomas R; Thomas, David L; Jackson, Sarah S; Prokunina-Olsson, Ludmila; Donnelly, Raymond P; Hartmann, Rune.

O'Brien TR; Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Thomas DL; Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Jackson SS; Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Prokunina-Olsson L; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Donnelly RP; Division of Biotechnology Research and Review II, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Hartmann R; Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark.

Clin Infect Dis ; 71(6): 1410-1412, 2020 09 12.

Article in English | MEDLINE | ID: covidwho-795543

Subject(s)

Betacoronavirus/physiology; Coronavirus Infections/drug therapy; Coronavirus Infections/immunology; Interferon-gamma/therapeutic use; Pneumonia, Viral/drug therapy; Pneumonia, Viral/immunology; COVID-19; Humans; Immunity, Innate/immunology; Interferons/metabolism; Lung/immunology; Lung/virology; Pandemics; SARS-CoV-2; Virus Replication/immunology; COVID-19 Drug Treatment

Keywords

MERS-CoV; SARS-CoV; innate immunity; severe acute respiratory syndrome; virology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interferon-gamma / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: Cid

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