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Naturally activated adaptive immunity in COVID-19 patients.
Yang, Xiaofeng; Dai, Tongxin; Zhou, Xiaobo; Qian, Hongbo; Guo, Rui; Lei, Lei; Zhang, Xingzhe; Zhang, Dan; Shi, Lin; Cheng, Yanbin; Hu, Jinsong; Guo, Yaling; Zhang, Baojun.
  • Yang X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Dai T; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, Shaanxi, China.
  • Zhou X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Qian H; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Guo R; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, Shaanxi, China.
  • Lei L; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, Shaanxi, China.
  • Zhang X; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Zhang D; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Shi L; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Cheng Y; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Hu J; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Guo Y; Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Zhang B; Department of Clinical Laboratory, The 8th hospital of Xi'an, Xi'an, Shaanxi, China.
J Cell Mol Med ; 24(21): 12457-12463, 2020 11.
Article in English | MEDLINE | ID: covidwho-796054
ABSTRACT
Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) has rapidly spread worldwide, threatening the health and lives of many people. Unfortunately, information regarding the immunological characteristics of COVID-19 patients remains limited. Herein, we collected blood samples from 18 healthy donors (HDs) and 38 COVID-19 patients to analyse changes in the adaptive immune cell populations and their phenotypes. We observed that the lymphocyte percentage moderately decreased, CD4 and CD8 T cell percentage among lymphocytes were similar, and B cell percentage was increased in COVID-19 patients in comparison to that in HDs. T cells, especially CD8 T cells, showed an enhanced expression of late activation marker CD25 and exhaustion marker PD-1. Importantly, SARS-CoV-2 infection increased the percentage of T follicular helper- and germinal centre B-like cells in the blood. The parameters in COVID-19 patients remained unchanged across various age groups. Therefore, we demonstrated that the T and B cells are activated naturally and are functional during SARS-CoV-2 infection. These data provide evidence that the adaptive immunity in most patients could be primed to induce a significant immune response against SARS-CoV-2 infection upon receiving standard medical care.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptive Immunity / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Limits: Adult / Female / Humans / Male Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15771

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adaptive Immunity / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Limits: Adult / Female / Humans / Male Language: English Journal: J Cell Mol Med Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Jcmm.15771