Your browser doesn't support javascript.
Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis.
Skrip, Laura; Derra, Karim; Kaboré, Mikaila; Noori, Navideh; Gansané, Adama; Valéa, Innocent; Tinto, Halidou; Brice, Bicaba W; Gordon, Mollie Van; Hagedorn, Brittany; Hien, Hervé; Althouse, Benjamin M; Wenger, Edward A; Ouédraogo, André Lin.
  • Skrip L; Institute for Disease Modeling, Bellevue, WA, USA. Electronic address: lskrip@idmod.org.
  • Derra K; IRSS-Clinical Research Unit of Nanoro, Burkina Faso.
  • Kaboré M; Ministry of Health, Teaching Hospital Yalgado Ouedraogo, Ouagadougou, Burkina Faso.
  • Noori N; Institute for Disease Modeling, Bellevue, WA, USA.
  • Gansané A; Centre National de Recherche et de Formation Sur le Paludisme, National Public Health Institute, Ouagadougou, Burkina Faso.
  • Valéa I; IRSS-Clinical Research Unit of Nanoro, Burkina Faso.
  • Tinto H; IRSS-Clinical Research Unit of Nanoro, Burkina Faso.
  • Brice BW; Centre des Operations de Réponses aux Urgences Sanitaires, Ouagadougou, National Public Health Institute, Burkina Faso.
  • Gordon MV; Institute for Disease Modeling, Bellevue, WA, USA.
  • Hagedorn B; Institute for Disease Modeling, Bellevue, WA, USA.
  • Hien H; Centre MURAZ, National Public Health Institute, Ouagadougou, Burkina Faso; IRSS, Programme de Recherche Sur les Politiques et les Systèmes de Santé, Bobo-Dioulasso, Burkina Faso.
  • Althouse BM; Institute for Disease Modeling, Bellevue, WA, USA; University of Washington, Seattle, WA, USA; New Mexico State University, Las Cruces, NM, USA.
  • Wenger EA; Institute for Disease Modeling, Bellevue, WA, USA.
  • Ouédraogo AL; Institute for Disease Modeling, Bellevue, WA, USA.
Int J Infect Dis ; 101: 194-200, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-796226
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. Warburg Therapy ADMINISTERED_TO Patients
Subject
Warburg Therapy
Predicate
ADMINISTERED_TO
Object
Patients
2. Warburg Therapy compared_with oxygen
Subject
Warburg Therapy
Predicate
compared_with
Object
oxygen
3. Warburg Therapy NEG_higher_than oxygen
Subject
Warburg Therapy
Predicate
NEG_higher_than
Object
oxygen
4. Engaged to be married PROCESS_OF Community
Subject
Engaged to be married
Predicate
PROCESS_OF
Object
Community
5. Warburg Therapy ADMINISTERED_TO Patients
Subject
Warburg Therapy
Predicate
ADMINISTERED_TO
Object
Patients
6. Warburg Therapy compared_with oxygen
Subject
Warburg Therapy
Predicate
compared_with
Object
oxygen
7. Warburg Therapy NEG_higher_than oxygen
Subject
Warburg Therapy
Predicate
NEG_higher_than
Object
oxygen
8. Engaged to be married PROCESS_OF Community
Subject
Engaged to be married
Predicate
PROCESS_OF
Object
Community
ABSTRACT

BACKGROUND:

Absolute numbers of COVID-19 cases and deaths reported to date in the sub-Saharan Africa (SSA) region have been significantly lower than those across the Americas, Asia and Europe. As a result, there has been limited information about the demographic and clinical characteristics of deceased cases in the region, as well as the impacts of different case management strategies.

METHODS:

Data from deceased cases reported across SSA through 10 May 2020 and from hospitalized cases in Burkina Faso through 15 April 2020 were analyzed. Demographic, epidemiological and clinical information on deceased cases in SSA was derived through a line-list of publicly available information and, for cases in Burkina Faso, from aggregate records at the Centre Hospitalier Universitaire de Tengandogo in Ouagadougou. A synthetic case population was probabilistically derived using distributions of age, sex and underlying conditions from populations of West African countries to assess individual risk factors and treatment effect sizes. Logistic regression analysis was conducted to evaluate the adjusted odds of survival for patients receiving oxygen therapy or convalescent plasma, based on therapeutic effectiveness observed for other respiratory illnesses.

RESULTS:

Across SSA, deceased cases for which demographic data were available were predominantly male (63/103, 61.2%) and aged >50 years (59/75, 78.7%). In Burkina Faso, specifically, the majority of deceased cases either did not seek care at all or were hospitalized for a single day (59.4%, 19/32). Hypertension and diabetes were often reported as underlying conditions. After adjustment for sex, age and underlying conditions in the synthetic case population, the odds of mortality for cases not receiving oxygen therapy were significantly higher than for those receiving oxygen, such as due to disruptions to standard care (OR 2.07; 95% CI 1.56-2.75). Cases receiving convalescent plasma had 50% reduced odds of mortality than those who did not (95% CI 0.24-0.93).

CONCLUSIONS:

Investment in sustainable production and maintenance of supplies for oxygen therapy, along with messaging around early and appropriate use for healthcare providers, caregivers and patients could reduce COVID-19 deaths in SSA. Further investigation into convalescent plasma is warranted until data on its effectiveness specifically in treating COVID-19 becomes available. The success of supportive or curative clinical interventions will depend on earlier treatment seeking, such that community engagement and risk communication will be critical components of the response.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: SARS-CoV-2 / COVID-19 Subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Risk factors Language: English Journal: Int J Infect Dis Clinical aspect: Etiology Year: 2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: SARS-CoV-2 / COVID-19 Subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Risk factors Language: English Journal: Int J Infect Dis Clinical aspect: Etiology Year: 2020
...