Neprilysin expression and functions in development, ageing and disease.
Mech Ageing Dev
; 192: 111363, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-797286
ABSTRACT
Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of substrates and physiological functions. It plays an important role in proteolytic processes in the kidney, cardiovascular regulation, immune response, cell proliferation, foetal development etc. It is an important neuropeptidase and amyloid-degrading enzyme which makes NEP a therapeutic target in Alzheimer's disease (AD). Moreover, it plays a preventive role in development of cancer, obesity and type-2 diabetes. Recently a role of NEP in COVID-19 pathogenesis has also been suggested. Despite intensive research into NEP structure and functions in different organisms, changes in its expression and regulation during brain development and ageing, especially in age-related pathologies, is still not fully understood. This prevents development of pharmacological treatments from various diseases in which NEP is implicated although recently a dual-acting drug sacubitril-valsartan (LCZ696) combining a NEP inhibitor and angiotensin receptor blocker has been approved for treatment of heart failure. Also, various natural compounds capable of upregulating NEP expression, including green tea (EGCG), have been proposed as a preventive medicine in prostate cancer and AD. This review summarizes the existing literature and our own research on the expression and activity of NEP in normal brain development, ageing and under pathological conditions.
Keywords
AICD; Ageing; Alzheimer's disease; Aß peptide; CALLA; CD10; HDACs; NEP inhibitors olfactory bulbs; amyloid-degrading enzyme; cancer; cognitive behaviour; cortex; diabetes; embryogenesis; endopeptidase 24.11; enkephalinase; epigenetic regulation; hippocampus; hypertension; memory; neprilysin; prenatal hypoxia; striatum
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aging
/
Neprilysin
/
Gene Expression Regulation, Enzymologic
/
Gene Expression Regulation, Neoplastic
/
Diabetes Mellitus, Type 2
/
Alzheimer Disease
/
SARS-CoV-2
/
COVID-19
/
Neoplasm Proteins
/
Neoplasms
Limits:
Animals
/
Humans
Language:
English
Journal:
Mech Ageing Dev
Year:
2020
Document Type:
Article
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