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The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.
Sun, Hua-Bao; Zhang, Yi-Ming; Huang, Li-Gui; Lai, Qi-Nan; Mo, Qun; Ye, Xin-Zhou; Wang, Tao; Zhu, Zhong-Zhen; Lv, Xiao-Lin; Luo, Yan-Ji; Gao, Shi-Ding; Xu, Jin-Song; Zhu, Hao-Hao; Li, Ting; Wang, Zhan-Ke.
  • Sun HB; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
  • Zhang YM; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Huang LG; Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Lai QN; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
  • Mo Q; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Ye XZ; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Wang T; Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.
  • Zhu ZZ; Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Lv XL; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
  • Luo YJ; Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.
  • Gao SD; Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Xu JS; Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Zhu HH; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
  • Li T; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
  • Wang ZK; Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.
PLoS One ; 15(9): e0239532, 2020.
Article in English | MEDLINE | ID: covidwho-798278
ABSTRACT
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / CD4-Positive T-Lymphocytes / Cytokines / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0239532

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / CD4-Positive T-Lymphocytes / Cytokines / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0239532