Pathophysiology of coronavirus disease 2019 for wound care professionals.
Int Wound J
; 17(6): 1935-1940, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-798871
ABSTRACT
There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes Coronavirus disease 2019 (COVID-19). The tissue tropism of SARS-CoV-2 includes not only the lung but also the vascular and integumentary systems. Angiotensin-converting enzyme 2 (ACE2) appears to be the key functional receptor for the virus. There is a prominent innate immune response to SARS-CoV-2 infection, including inflammatory cytokines, chemokines, the complement system, and acute phase proteins. The pathophysiologic significance of SARS-COV-2 and host immune system interaction, and COVID-19-associated coagulopathy instigating microvascular injury syndrome mediated by activation of complement pathways, and an associated procoagulant state is important for wound care professionals to understand.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Wounds and Injuries
/
Health Personnel
/
COVID-19
/
Immunity, Innate
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Int Wound J
Year:
2020
Document Type:
Article
Affiliation country:
Iwj.13483
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